5-(Acetyl-(3-(acetyl-(3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodophenyl)amino)-2- hydroxypropyl)amino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide; 5,5'-((2-Hydroxytrimethylene)bis(acetylimino))bis(N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodoisophthalamide);

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

January-December 1986

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

no guideline available

Guideline:

other:

Principles of method if other than guideline:

Aqueous and methanol solutions of iodixanol were prepared and stored in 2 ml volumetric flasks with a plastic stopper. The bottles were inspected visually during 10 months.

GLP compliance:

not specified

Test material

Reference

Name:

Unnamed

Type:

Constituent

Results and discussion

Solubility in organic solvents / fat solubility

Medium:

methanol

Solubility:

ca. 100 g/L

Temp.:

4 °C

Any other information on results incl. tables

The solubility of iodixanol in methanol is approximately 0.1g/ml at 4^oC and at room temperature. The experiment was performed January-December 1986.

Performance: Solution of iodixanol was prepared in 2ml volumetric flsk with a plastic stopper. The bottles were inspected visually during 10 months. Concentration, storage conditions and results are given in Table 1.

Solvent	Concentration w/v %	Temperature ^oC	Visual inspection
Methanol	10	4	Clear solution
Methanol	10	RT	Clear solution
Methanol	15	4	Clear solution
Methanol	15	RT	Clear solution