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EC number: 615-083-4 | CAS number: 70223-33-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28.06.2000-30.06.2000
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DS/ISO 14669 (1999): Water Quality - Determination of acute lethal toxicity to marine copepods
- GLP compliance:
- no
Test material
- Reference substance name:
- (1R,3S)-2,2-Dimethyl-3-(2-oxopropyl)cyclopropanecarboxylic acid
- Cas Number:
- 70223-33-5
- Molecular formula:
- C9H14O3
- IUPAC Name:
- (1R,3S)-2,2-Dimethyl-3-(2-oxopropyl)cyclopropanecarboxylic acid
- Test material form:
- solid: crystalline
Constituent 1
Test solutions
- Details on test solutions:
- 0, 1, 2, 5, 10, 20, 50 & 100 mg/l
Test organisms
- Test organisms (species):
- other: Arcartia tonsa
- Details on test organisms:
- TEST ORGANISM
- Common name: Marine copepod
- Strain: Arcartia tonsa
- Source: Originally from the North Sea, now cultured at DHI
Study design
- Test type:
- static
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 20º
- pH:
- 8.0
- Salinity:
- 31 ‰
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 50 ml glass beaker (Pyrex)
- Fill volume: 25 ml
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 5
- No. of vessels per vehicle control (replicates): 6
TEST MEDIUM / WATER PARAMETERS
- Source of dilution water: Natual Sea water obtained south east of Anholt in a depth of 25 m.
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light: 8 hours dark
TEST CONCENTRATIONS
- Test concentrations: 0, 1, 2, 5, 10, 20, 50, 100 mg/l - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorphenol, testet every 3 month
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 20 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- LC10
- Effect conc.:
- 19.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: -16.7-40.8
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 62.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 41.3-114
- Details on results:
- In the test at 20 mg/l one beaker was found to have a mortality at 100%, compared to the others with a max of 1 out of 5 death. There is a suspicion that this beaker was poluted. Because of the unsertainty about the cause of the observed mortality at 20 mg/l it was decided to use the whole dataset. This result in a somehow conservative estimat of the toxicity of the substance.
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
The sensitivity of the animals was tested with 3,5 -dichlorphenol and calculation showed an LC50(48h) 1.27 mg/l. This is in between the normal findings (LC50: 0.5 -1.5 mg/l). The sensitivity of the animals is assessed to be normal.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- Mortality in controls < 10 %, oxygen > 60%, mortality with reference test within acceptable range: 0.5-1.5 mg/l
- Conclusions:
- The substance is found to have a LC50 (48h): 62.3 mg/l for Arcartia tonsa. (This is considered to be a very conservative result)
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