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EC number: 611-591-5 | CAS number: 57903-73-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Read across studies
PETIA: rat, oral: NOAEL systemic = 75mg/kg (OECD 422, GLP, 2010)
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
No data are available for Pentaerythritol, olig. react. prod. with 1-chloro-2,3-epoxypropane, react. prod. with acrylic acid. Thus read across was performed to the structurally similar substance 2-Propenoic acid, reaction products with pentaerythritol (PETIA, CAS 1245638-61-2), which in comparison to Pentaerythritol, olig. react. prod. with 1-chloro-2,3-epoxypropane, react. prod. with acrylic acid lacks the chain elements derived from 1-chloro-2,3 epoxipropane in between the pentaerythritol and acrylic acid groups. Consequently this lead to a lower molecular weight of app. 300g/mol compared to app 850g/mol for the oligomere. Both substances are liquids with a low vapour pressure << 0.01hPa and low water solubility of approximately 500-700mg/l. Because of the increased chain length, the log Pow for Pentaerythritol, olig. react. prod. with 1-chloro-2,3-epoxypropane, react. prod. with acrylic acid is slightly higher than the value for PETIA (>3 compared to 1-3). Both substances are moderate skin sensitizers, but due to the higher amount of acrylic acid on a weight per weight basis, which is presumably quickly hydrolysed, PETIA shows an increased irritation potential, i.e., skin irritation, eye corrosion and low acute oral toxicity as a consequence of severe mucosal irritation / erosion. Thus using data from PETIA is a reasonable worst case approach to evaluate the toxicity of Pentaerythritol, olig. react. prod. with 1-chloro-2,3-epoxypropane, react. prod. with acrylic acid.
Pentaerythritol triacrylate was tested in an OECD 422 combined repeated dose/reproduction and developmental toxicity screening study via oral route with CRL:CD(SD) rats at concentrations of 0, 25, 75 and 200 mg/kg. Test substance-related clinical findings were noted in a dose-related manner across all dosage levels and included salivation or evidence thereof, yellow and red material primarily around the mouth, and wiping of mouth in the bedding (females only). Incidences of rales were also noted in the 75 and 200 mg/kg bw/day group males and females sporadically during the treatment period. All of the aforementioned clinical findings were primarily noted at the time of dose administration and/or approximately 1 hour following dose administration, and were attributed to the irritative properties of the test substance, and therefore, were not considered adverse. The indicated test substance-related findings at 75 and 200 mg/kg bw/day relating to mortality/morbidity, adrenal gland weights, neutrophil counts, macroscopic and/or microscopic findings of the stomach, adrenal cortex and thymus were attributed to the irritative properties of the test substance and corresponding stress, rather than systemic toxicity. Based on test substance-related lower mean body weight gains during the overall study period for the 200 mg/kg bw/day males as well as a lower mean body weight on day 27, the NOAEL for systemic toxicity was considered to be 75 mg/kg bw/day.
Justification for classification or non-classification
No specific target organ toxicity was oberseved. The primary effect in the repeated dose study was local irritation. Thus Pentaerythritol, olig. react. prod. with 1-chloro-2,3-epoxypropane, react. prod. with acrylic acid does not have to be classified according to 67/548/EEC or CLP/EU-GHS.
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