Registration Dossier
Registration Dossier
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EC number: 615-086-0 | CAS number: 70225-05-7
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Long-term toxicity to fish - read across data
Read-across results of a 14-day study with surrogate, tri-2-ethylhexyl trimellitate (TOTM) indicate that the submission substance is not expected to produce chronic toxicity to fish at its maximum water solubility limits.
Key value for chemical safety assessment
Additional information
Chronic fish toxicity data were not available for the submission substance, CAS No. 70225-05-7. However, there are sufficient read-across chronic toxicity fish data reported for tri-2-ethylhexyl trimellitate (TOTM)(CAS 3319-31-1), a related trimellitate surrogate, to help assess the long-term toxicity potential in fish for the submission substance.
A chronic 14-day study has been carried out in medaka with tri-2-ethylhexyl trimellitate (TOTM) at exposure loading levels of 18.8, 37.5 and 75 mg/L. Results indicated that TOTM did not cause any mortality in medaka in the prolonged fish toxicity test. The 14-day LL50 was determined to be >75 mg/L and the 14-day NOEL was determined to be > 75 mg/L, which are orders of magnitude above the maximal water solubility of TOTM. These findings indicate that tri-2-ethylhexyl trimellitate (CAS No. 3319-31-1) is not expected to cause any chronic toxicity to fish at its maximum water solubility limit.
Based on the read-across chronic non-toxicity findings for the surrogate trimellitate and owing to their chemical similarity, the submission substance, CAS No. 70225-05-7, also would not be expected to be cause any chronic toxicity to fish at its maximal water solubility limit.
The findings are consistent with the structurally similarity and close physicochemical characteristics (e.g., low water solubility) between these two trimellitate materials. The absence of any chronic toxicity may be due in part to their low water solubility, resulting in low exposure potential in the aqueous compartment as well as to the ability of organisms to metabolize or biodegrade the test materials.
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