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EC number: 619-290-0 | CAS number: 97780-06-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1400 (Fish Early-life Stage Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reference substance 002
- Cas Number:
- 97780-06-8
- Test material form:
- solid
- Details on test material:
- Purity: 99.2%
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
- Remarks:
- dimethylformamide
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 87 d
Test conditions
- Hardness:
- 128 to 140 mg/L as CaCO3 (negative control) and 136 to 144 mg/L as CaCO3 (5.4 mg a.s./L)
- Test temperature:
- 12 ± 1ºC
- pH:
- 7.8 to 8.4
- Dissolved oxygen:
- ≥ 6.8 mg/L (63% of saturation)
- Conductivity:
- 351 to 403 μS/cm (negative control) and 354 to 397 μS/cm (5.4 mg a.s./L)
- Nominal and measured concentrations:
- Nominal: 0.38, 0.75, 1.5, 3.0, 6.0 mg a.s./L
Measured: 0.33, 0.70, 1.3, 2.8, 5.4 mg a.s./L - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 87 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 5.4 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: time to hatch, hatching success, time to swim-up, survival and growth
- Remarks on result:
- other: highest concentration tested
- Key result
- Duration:
- 87 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 5.4 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: time to hatch, hatching success, time to swim-up, survival and growth
- Remarks on result:
- other: highest concentration tested
- Key result
- Duration:
- 87 d
- Dose descriptor:
- other: MATC
- Effect conc.:
- > 5.4 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: time to hatch, hatching success, time to swim-up, survival and growth
- Remarks on result:
- other: highest concentration tested
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 87 d NOEC (Oncorhynchus mykiss): 5.4 mg a.s./L (time to hatch, hatching success, time to swim-up, survival and growth) (Highest concentration tested)
87 d LOEC and MATC (Oncorhynchus mykiss): >5.4 mg a.s./L (time to hatch, hatching success, time to swim-up, survival and growth) (Highest concentration tested) - Executive summary:
The effects of test substance on the early life stages (based on time to hatch, hatching success, time to swim-up, survival and growth) of rainbow trout (Oncorhynchus mykiss) were determined in an unaerated flowthrough system for 87 days. The test was conducted in based on to the OECD Guideline for Testing of Chemicals, 210 and U.S. Environmental Protection Agency Series 850 – Ecological Effects test Guidelines, OPPTS Guideline 850.1400. Treatments consisted of a dilution water control, solvent control (0.1 mL dimethylformamide/L) and five nominal concentrations of 0.38, 0.75, 1.5, 3.0 and 6.0 mg a.s./L. The corresponding mean, measured concentrations were 0.33, 0.70, 1.3, 2.8 and 5.4 mg a.s./L.
During the embryo incubation period, the embryos were observed daily and any dead embryos or embryos with fungus were counted and removed. Daily observations were made during the post-hatch exposure period to evaluate the numbers of individuals exhibiting clinical signs of toxicity or abnormal behaviour. Post-hatch growth of the rainbow trout was measured at the end of the test (study day 87, 60 days post-hatch).
There were no treatment-related effects on hatching success, time to hatch, time for larvae to swim-up, or post-hatch growth and survival. The NOEC, based on mean, measured test concentrations, and the time to hatch, hatching success, time to swim-up, survival and growth was 5.4 mg a.s./L. The LOEC and MATC were >5.4 mg a.s./L, the highest concentration tested.
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