Registration Dossier
Registration Dossier
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EC number: 604-351-6 | CAS number: 143390-89-0
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
- Reference Type:
- other: FOCUS calculation
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA Guideline Subdivision N 161-1 (Hydrolysis)
- GLP compliance:
- yes
Test material
- Reference substance name:
- methyl (2E)-2-methoxyimino-2-[2-[(2-methylphenoxy)methyl]phenyl]acetate
- EC Number:
- 604-351-6
- Cas Number:
- 143390-89-0
- Molecular formula:
- C18 H19 N O4
- IUPAC Name:
- methyl (2E)-2-methoxyimino-2-[2-[(2-methylphenoxy)methyl]phenyl]acetate
- Details on test material:
- - Name of test material (as cited in study report): [14C]242009; also denominated [14C]BAS 490 F
- Lot No.: 39/149-1 and L48/92 (Z-isomer)
- Radiochemical purity: > 98% (incl. Z-isomer 242010)
- Specific activity: 3.578 MBq/mg
- Locations of the label: (E)-2-[2-(2-Methylphenoxy)-methyl]-[ring-U-14C]phenyl-2-(methoxyimido)=acetic acid methyl ester ("ring-B-14C-labelled BAS 490 F")
Constituent 1
- Radiolabelling:
- yes
Study design
- Analytical monitoring:
- yes
- Buffers:
- - pH: 5.0
- Type and final molarity of buffer: <= 0.05 M
- Composition of buffer: Citrate sodium hydroxide
- pH: 7.0
- Type and final molarity of buffer: <= 0.05 M
- Composition of buffer: Phosphate
- pH: 9.0
- Type and final molarity of buffer: <= 0.05 M
- Composition of buffer: Boric acid, potassium chloride sodium hydroxide - Details on test conditions:
- STOCK SOLUTION
- Preparation: 2.4 mg radio labelled test substance were dissolved in 10 ml acetonitril
- Storage: under nitrogen conditions
SAMPLES PREPARATION
- Preparation: 0.5 ml stock solution were added to buffer solution and sterilized through a filter (pore-diameter 0.22 µm). 20 ml aliquots of the sterilized solution were transferred in 25 ml tubes with ground joint and stored in the dark at 25 ± 1 °C.
- Sterility check: after sterile filtration, 15 and 30 days
Duration of testopen allclose all
- Duration:
- 30 d
- pH:
- 5
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.23 mg/L
- Duration:
- 30 d
- pH:
- 7
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.23 mg/L
- Duration:
- 30 d
- pH:
- 9
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.23 mg/L
- Number of replicates:
- 2
Results and discussion
Total recovery of test substance (in %)open allclose all
- % Recovery:
- 97
- pH:
- 5
- Temp.:
- 25 °C
- Duration:
- 30 d
- % Recovery:
- 54
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 30 d
- % Recovery:
- 0
- pH:
- 9
- Temp.:
- 25 °C
- Duration:
- 4 d
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 5
- Temp.:
- 25 °C
- DT50:
- ca. 821.8 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: DT50 values estimated by FOCUS modelling
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- ca. 35 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: DT50 values estimated by FOCUS modelling
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- ca. 0.38 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: DT50 values estimated by FOCUS modelling
- Details on results:
- Half-lifes of BAS 490 F based on measurements:
at pH 5 (25 °C) = ca. 875 d
at pH 7 (25 °C) = ca. 34 d
at pH 9 (25 °C) = ca. 0.29 d
Applicant's summary and conclusion
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