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EC number: 500-241-6 | CAS number: 69011-36-5 1 - 2.5 moles ethoxylated
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
EC10 (30d): 0.1 - 1 mg/L QSAR estimation)
Key value for chemical safety assessment
Additional information
The calculated PEC/PNEC ratios for the freshwater and marine compartment were < 1 for all uses. In conclusion, the environmental exposure assessment for the substance indicates no risk for the aquatic compartment (all RCR < 1; please refer to Chapter 9 and 10 of the Chemical Safety Report for detailed information). In accordance to column 2 of Annex IX, section 9.4 of Regulation (EC) No. 1907/2006, no further tests on the effects of the substance to terrestrial organisms are needed and consequently further testing was omitted.
Experimental data on long-term toxicity of Isotridecanol, ethoxylated, < 2.5 EO to fish are not available. The available acute toxicity data on fish, aquatic invertebrates and algae indicate that Daphnia are the most sensitive organisms with an effect concentration EL50 (48h) of 0.544 mg/L (geom. mean measured). For fish a LL50 (96h) > 1.1 mg/L (geom. mean measured) was determined toxic effects were not observed. The ErC50 (72h) determined for algae was 3.4 mg/L (meas. arith. mean). Experimental data on the chronic toxicity are available for aquatic invertebrates and algae. The NOEC (21 d) determined for the reproduction rate of Daphnia magna is 0.218 mg/L (TWA). The ErC10 (72h) for algae is 1.33 mg/L (meas. arith. mean). The chronic effect concentrations for fish, calculated by QSAR, and the available experimental data on D. magna and algae are in the same order of magnitude. The chronic toxicity to fish was estimated by QSAR using a mixtureadditivityapproach. The QSAR model is based on the log Kow as predictor variable. Alcohol ethoxylates are assumedaffect aquatic organismsbynon-polar narcosis and thus the effects are related to the log Kow.The EC10 calculated by QSAR is in the range of 0.1 – 1 mg/L (EC10 (30 d): 0.236 mg/L). A higher sensitivity of fish compared to daphnia or algae is not likely.
Conclusion
The environmental exposure assessment indicates no risk for the
aquatic compartment.
The estimated chronic effect concentration for fish and the
experimentally determined NOEC for aquatic invertebrates are in the same
order of magnitude. Based on the available acute data set, it is not
expected that fish are more sensitive than daphnia.
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