Registration Dossier
Registration Dossier
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EC number: 478-900-1 | CAS number: 6156-18-9
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The aerobic biodegradation of 2,2 -bis(methylthio)propane has been examined through 3 studies, performed according to the OECD guidelines 301F, 301D and 302C. Under test conditions, the substance was considered as not readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The aerobic readily biodegradation of 2,2 -bis(methylthio)propane has been examined through 2 studies, performed according to the OECD guidelines (Gancet 2007 and Shen 2008).
During the first study (Gancet, 2007) the biodegradation was checked by manometric respirometry. The percentage of biodegradation 2,2 -bis(methylthio)propane was 0 % at the end of the test (28 days). The test item did not demonstrate any inhibiting effect on the micro-organisms.
A second study (Shen 2008) was performed according to the OECD 301D guideline. Measurements of dissolved oxygen were performed on two chambers from the control, reference, and treatment groups on days 0, 7, 14, 21 and 28. The percent biodegradation of 2,2 -bis(methylthio)propane was calculated as 4.05%, 5.60%, 6.85% and 7.63% on days 7, 14, 21 and 28.
Due to the results obtained, the substance is considered as not readily biodegradable.
Finally, the study of inherent biodegradation of bismethylthiopropane was performed by the modified MITI Test (II) according to OECD 302C and GLP requirements (Zhao, 2012). The measured concentrations of the control group at the beginning and the end of the test was 31.0 mg/L and 28.1 mg/L, respectively, indicating that the test substance had not been significantly degraded in the abiotic manner. The test is considered to be valid since 87.1% of degradation was obtained after 28 days for the reference substance. The calculated percentage biodegradation of the test substance was 10.7% in the 28th day. It showed that this test substance is not inherently biodegradable.
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