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EC number: 470-680-5 | CAS number: 958872-63-4
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD 106 & EC guideline study C.18 and GLP
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 106 (Adsorption - Desorption Using a Batch Equilibrium Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.18 (Adsorption / Desorption Using a Batch Equilibrium Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- batch equilibrium method
- Media:
- soil
Test material
- Reference substance name:
- -
- EC Number:
- 470-680-5
- EC Name:
- -
- Cas Number:
- 958872-63-4
- Molecular formula:
- C16H30O3
- IUPAC Name:
- 1-[2-({1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl}oxy)propoxy]propan-2-ol; 1-{[1-({1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl}oxy)propan-2-yl]oxy}propan-2-ol; 2-[2-({1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl}oxy)propoxy]propan-1-ol; 2-{[1-({1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl}oxy)propan-2-yl]oxy}propan-1-ol
- Details on test material:
- Batch: V04/010-13N, mixture of isomers, manufactured: 2005-03-01, expiry: 2008-03-01, purity 97.9 % cf AZ 212
Constituent 1
- Radiolabelling:
- no
Study design
- Test temperature:
- 20 ± 2°C
Batch equilibrium or other method
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: all concentrations.
- Details on matrix:
- EURO-Soils 1-5 acc to "EUROSOlLS II, Laboratory Reference Materials for Soil-related Studies", JRC European Commission, 1999
- Details on test conditions:
TEST SYSTEM
- Type, size and further details on reaction vessel: 50 ml polyethylene centrifugation tubes with screw cap
- Soil / solution ratio 1:25; sample #n = EURO-soil n (mean of 2 replicates)
- Number of reaction vessels/concentration: Duplicates
- Method of preparation of test solution: 10 mg/l was tested in 5 different soils. Aliquots of the stock solution and dilutions were spiked with a pipette into the vessel to obtain the final concentration in 50 ml 0.01 M CaCl2.
Duration of adsorption equilibrationopen allclose all
- Sample No.:
- #1
- Duration:
- 48 h
- Initial conc. measured:
- 10 other: mg/L
- pH:
- 5.6
- Temp.:
- 20 °C
- Sample No.:
- #2
- Duration:
- 48 h
- Initial conc. measured:
- 10 other: mg/L
- pH:
- 7.7
- Temp.:
- 20 °C
- Sample No.:
- #3
- Duration:
- 48 h
- Initial conc. measured:
- 10 other: mg/L
- pH:
- 5.4
- Temp.:
- 20 °C
- Sample No.:
- #4
- Duration:
- 48 h
- Initial conc. measured:
- 10 other: mg/L
- pH:
- 6.7
- Temp.:
- 20 °C
- Sample No.:
- #5
- Duration:
- 48 h
- Initial conc. measured:
- 10 other: mg/L
- pH:
- 3.5
- Temp.:
- 20 °C
Duration of desorption equilibrationopen allclose all
- Sample no.:
- #1
- Duration:
- 48 h
- Conc. of adsorbed test mat.:
- 19 mg/kg soil d.w.
- pH:
- 5.6
- Temp.:
- 20 °C
- Sample no.:
- #2
- Duration:
- 48 h
- Conc. of adsorbed test mat.:
- 22 mg/kg soil d.w.
- pH:
- 7.7
- Temp.:
- 20 °C
- Sample no.:
- #3
- Duration:
- 48 h
- Conc. of adsorbed test mat.:
- 23 mg/kg soil d.w.
- pH:
- 5.4
- Temp.:
- 20 °C
- Sample no.:
- #4
- Duration:
- 48 h
- Conc. of adsorbed test mat.:
- 11.6 mg/kg soil d.w.
- pH:
- 6.7
- Temp.:
- 20 °C
- Sample no.:
- #5
- Duration:
- 48 h
- Conc. of adsorbed test mat.:
- 40.2 mg/kg soil d.w.
- pH:
- 3.5
- Temp.:
- 20 °C
Results and discussion
Results: Batch equilibrium or other method
- Adsorption and desorption constants:
- EURO-soil 1: Koc=942 cm3/g, Kd= 31 cm3/g, Kdes=107 cm3/g
EURO-soil 2: Koc=502 cm3/g, Kd= 12 cm3/g, Kdes=31 cm3/g
EURO-soil 3: Koc=181 cm3/g, Kd= 6 cm3/g, Kdes= 5 cm3/g
EURO-soil 4: Koc=221 cm3/g, Kd= 3 cm3/g, Kdes= 2 cm3/g
EURO-soil 5: Koc=497 cm3/g, Kd= 22 cm3/g, Kdes=24 cm3/g - Recovery of test material:
- EURO-soil 1: desorption = 20 %
EURO-soil 2: desorption = 45 %
EURO-soil 3: desorption = 84 %
EURO-soil 4: desorption = 77 %
EURO-soil 5: desorption = 53 % - Concentration of test substance at end of adsorption equilibration period:
- EURO-soil 1: 101.7 mg/kg soil
EURO-soil 2: 49.9 mg/kg soil
EURO-soil 3: 27.9 mg/kg soil
EURO-soil 4: 13.0 mg/kg soil
EURO-soil 5: 79.9 mg/kg soil - Concentration of test substance at end of desorption equilibration period:
- EURO-soil 1: 77.6 mg/kg soil
EURO-soil 2: 26.6 mg/kg soil
EURO-soil 3: 4.3 mg/kg soil
EURO-soil 4: 1.1 mg/kg soil
EURO-soil 5: 37.4 mg/kg soil
Mass balance (%) at end of adsorption phaseopen allclose all
- Sample no.:
- #1
- Duration:
- 48 h
- % Adsorption:
- 96.7
- Sample no.:
- #2
- Duration:
- 48 h
- % Adsorption:
- 92.2
- Sample no.:
- #3
- Duration:
- 48 h
- % Adsorption:
- 85.9
- Sample no.:
- #4
- Duration:
- 48 h
- % Adsorption:
- 72.7
- Sample no.:
- #5
- Duration:
- 48 h
- % Adsorption:
- 95.7
Mass balance (%) at end of desorption phaseopen allclose all
- Sample no.:
- #1
- Duration:
- 48 h
- % Desorption:
- 20
- Sample no.:
- #2
- Duration:
- 48 h
- % Desorption:
- 45
- Sample no.:
- #3
- Duration:
- 48 h
- % Desorption:
- 84
- Sample no.:
- #4
- Duration:
- 48 h
- % Desorption:
- 77
- Sample no.:
- #5
- Duration:
- 48 h
- % Desorption:
- 53
- Transformation products:
- not measured
- Details on results (Batch equilibrium method):
- desorption <= 24 % (overall mean for each soil) for desorption isotherms
Any other information on results incl. tables
The test item showed a moderate tendency to adsorb to the five test soils. A correlation between the degree of adsorption and the organic carbon content of the soil can be assumed. The test item can be considered to have a medium to low mobility in soil (according to MCCALL classification scheme, a substance with Koc 150 - 500 can be classified to have a medium mobility and with Koc 500 - 2000 to have a low mobility). Adsorption of the test substance is not completely reversible, as % desorption was 20 - 84 % in the desorption kinetics (please refer to 4.3.2) and ≤ 24 % (overall mean for each soil) for desorption isotherms.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Dipropyleneglycolisobornylether (mixture of isomers) showed a moderate tendency to adsorb to the five test soils. A correlation between the degree of adsorption and the organic carbon content of the soil can be assumed. Dipropyleneglycolisobornylether (mixture of isomers) can
be considered to have a medium to low mobility in soil (according to MCCALL classification scheme, a substance with Koc 150 - 500 can be classified to have a medium mobility and with Koc 500 - 2000 to have a low mobility). Adsorption of Dipropyleneglycolisobornylether (mixture of isomers) is not completely reversible, as % desorption was 20 - 84 % in the desorption kinetics (please refer to 4.3.2) and ≤ 24 % (overall mean for each soil) for desorption isotherms. - Executive summary:
The adsorption/desorption of the test item Dipropyleneglycolisobornylether (mixture of isomers) was determined according to OECD Guideline 106 and Directive 2001/59/EC, Method C.18. EURO standard soils no. 1, 2, 3, 4 and 5 were used as test system. Soil/solution ratio 1:25 was used for all soils. Based on preliminary tests the adsorption and desorption equilibration times were 48 hours. The amount of test item absorbed on the soils was calculated from the depletion of the test item in the solution (indirect method). A mass balance established the stability of the test item and confirmed that there was no adsorption to the test vessel. In the advanced study only the aqueous phase was analysed for soils 3 -5. For soils 1 and 2 the mass balance resulted in recoveries <90% and therefore, both aqueous and soil phase was analysed in the advanced study. Based on water solubility and on the results of preliminary studies the concentrations 0.5, 1, 5, 10 and 50 mg/l were selected as nominal concentrations. Dipropyleneglycolisobornylether (mixture of isomers) showed a moderate tendency to adsorb to the five test soils. A correlation between the degree of adsorption and the organic carbon content of the soil can be assumed. Dipropyleneglycolisobornylether (mixture of isomers) can be considered to have a medium to low mobility in soil (according to MCCALL classification scheme, a substance with Koc 150 - 500 can be classified to have a medium mobility and with Koc 500 - 2000 to have a low mobility). Adsorption of Dipropyleneglycolisobornylether (mixture of isomers) is not completely reversible, as % desorption was 20 - 84 % in the desorption kinetics and ≤ 24 % (overall mean for each soil) for desorption isotherms.
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