Registration Dossier
Registration Dossier
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EC number: 458-880-0 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 May 2003 to 28 August 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- March 1989
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- EU Comission Directive 1999/11/EC of March 1999 (Official Journal No L 77/8)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.5
- Temp.:
- 22.5 °C
- Remarks on result:
- other: pH not relevant
- Details on results:
- The deadtime (to) was determined as 2.191 minutes (mean of two determinations).
The regression equation produced was:
log10k= -0.88563 + 0.32838 log10Pow (R = 0.97325).
The test substance chromatographed as a single peak with a mean retention time from the duplicate injections of 4.079 minutes. This produced a partition coefficient of:
log10 Pow = 2.5004.
Duplicate blank solutions showed no peaks in the chromatograms at the characteristic retention time of the test substance.
The analytical data for the reference compounds and the test substance are adhered in "T-71 - analytical data partition coefficient.pdf". - Conclusions:
- The partition coefficient of T-71 was found to be log10 Pow = 2.50 at 22.5 °C.
Reference
Description of key information
Log Pow 2.5 at 22.5 °C - HPLC method (EU Method A.8, OECD guideline 117)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.5
- at the temperature of:
- 22.5 °C
Additional information
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