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Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

29 May 2003 to 28 August 2003

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)

Version / remarks:

May 1981

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Key result

Medium:

standard fat

Solubility:

< 0.025 g/kg solvent

Temp.:

37 °C

Test substance stable:

yes

Details on results:

The detector response was found to be linear over the concentration range 2.5288 to 20.230 mg/l, with a correlation coefficient of 0.99963.
There was no observable absorbance in two of the test solutions (tests 24A and 24B at 30°C). The other test solutions exhibited small absorbance, although none were greater than that of the most dilute calibration standard (2.5288 mg/l). The fat solubility of the test solutions is therefore seen to be less than the concentration of the lowest standard present. The fat solubility of T-71 was found to be less than 0.025 g/kg Standard Fat at 37 °C.
The mean recoveries obtained were 101.5 % (3.1725 mg/l) and 106.8 % (6.3450 mg/l) showing that the test substance could be quantitatively analysed.
No peaks were observed in the spectra of the blank solutions indicating that the analytical method was free from interference.

The analytical results can be found in the attachment "T-71 - analytical results fat solubility.pdf".

Conclusions:

The fat solubility of T-71 was found to be as less than 0.025 g/kg Standard Fat at 37 °C.

Description of key information

fat solubility <0.025 g/kg standard fat at 37 °C (OECD giudeline 116)

Additional information

The fat solubility of T-71 is < 2.5 mg/100g standard fat at 37 °C.