Registration Dossier
Registration Dossier
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EC number: 457-310-8 | CAS number: 127733-97-5 PLATINUM(2+), TETRAAMMINE-, (SP-4-1)-, DIACETATE (9CI)
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 August - 21 September 2004
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, conducted to GLP. No reporting of impurity identification.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Limited reporting detail - missing information on impurity content
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- (of Directive 92/69/EEC)
- Deviations:
- yes
- Remarks:
- Limited reporting detail - missing information on impurity content
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- 799 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7
- Conclusions:
- The water solubility of platinum(II) tetraammine diacetate was determined to be 799 g/L at a temperature of 20 deg C, indicating it to be very water soluble (> 10000 mg/L).
- Executive summary:
In a guideline-compliant study, conducted to GLP, the water solubility of platinum(II) tetraammine diacetate was determined to be 799 g/L at a temperature of 20 deg C, indicating a very high degree of water solubility.
Reference
| Sample number | Amount of test item [g] | Added volume of water [mL] | Shaking time at 30 deg C [hours] | Analysed concentration of test item [g/L] | pH |
| 1 | 5.919 | 3 | 24 | 799 | 7.0 |
| 2 | 5.931 | 3 | 24 | 801 | 7.0 |
| 3 | 5.920 | 3 | 48 | 809 | 7.0 |
| 4 | 5.916 | 3 | 48 | 790 | 7.0 |
| 5 | 5.918 | 3 | 72 | 797 | 7.0 |
| 6 | 5.908 | 3 | 72 | 797 | 7.0 |
Description of key information
The water solubility of platinum(II) tetraammine diacetate was determined to be 799 g/L at a temperature of 20 deg C (Mekelburger, 2004e), indicating a very high water solubility.
In a guideline-compliant study, conducted to GLP, the water solubility of platinum(II) tetraammine diacetate was determined to be 799 g/L at a temperature of 20 deg C, indicating a very high degree of water solubility.
Key value for chemical safety assessment
- Water solubility:
- 799 g/L
- at the temperature of:
- 20 °C
Additional information
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