2-Propenoic acid, 2-[2-(ethenyloxy)ethoxy]ethyl ester

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

between August 29th 2003 and 27th November 2003

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Date of inspection: November 18th - 22nd 2002 Date of Signature: March 2003

Type of method:

flask method

Water solubility:

18.4 g/L

Temp.:

20 °C

pH:

>= 5.82 - <= 5.9

Details on results:

In conclusion, the water solubility of 2-(2’-Vinyloxy ethoxy) ethyl acrylate at 20°C was determined to be 18.4 g/l   

The determination of the water solubility of 2-(2’-Vinyloxy ethoxy) ethyl acrylate was performed according to the EEC Directive 92/69, A.6 ”Water Solubility” (1992) and the OECD guideline No. 105, ”Water Solubility” (1995) using the flask shake method.

 

The saturation concentration of 2-(2’-Vinyloxy ethoxy) ethyl acrylate at room temperature was estimated by a simplified flask method in the preliminary test to be higher than 10-2 g/l. Therefore, the flask shaking test was performed.

 

The test item samples were shaken for 24 hours, 48 hours and 72 hours, respectively at 30°C and equilibrated for another 24 hours at 20.0°C. Afterwards the concentration of the samples was determined. The measured results differ by less than 15 %. Therefore the study is considered to be valid. The results of the individual measurements of the main test are summarised in Table 2. The tabulated values represent rounded results, which were obtained by calculation using the exact raw data.

 

A typical chromatogram of a standard solution is given in Figure 1. A typical chromatogram of a sample solution after 72 hours of incubation is given in Figure 2. The calibration data for test item-standards are given in Table 6. The r² fit was 1.0000 (optimum). This reflects the linearity of the HPLC-system within the calibration range of 1.375 µg/ml to 137.52 µg/ml of the test item.

 

The water solubility was not corrected for the purity of the test item

Table 2:     Results of the water solubility of 2-(2’-Vinyloxy ethoxy) ethyl acrylate

  

Sample No.	Shaking time at 30°C	Concentration analysed [mg/l]	Concentration calculated [g/l]	Water solubility calculated [g/l]
1	72	46.586	18.63
2		46.628	18.65
3	48	46.168	18.47	18.38
4		46.212	18.48	SD = ± 0.28
5	24	45.070	18.03
6		45.097	18.04

 

The saturation mass concentration is calculated from the bold values.

 

SD = standard deviation

Conclusions:

The water solubility of 2-(2’-Vinyloxy ethoxy) ethyl acrylate at 20°C was determined to be 18.4 g/l

Executive summary:

The determination of the water solubility of 2-(2’-Vinyloxy ethoxy) ethyl acrylate was performed according to the EEC Directive 92/69, A.6 ”Water Solubility” (1992) and the OECD guideline No. 105, ”Water Solubility” (1995) using the flask shake method.

The water solubility of 2-(2’-Vinyloxy ethoxy) ethyl acrylate at 20°C was determined to be:

 

18.4 g/l   (standard deviation ± 0.3 g/l).

Description of key information

The water solubility of 2-(2’-Vinyloxy ethoxy) ethyl acrylate at 20°C was determined to be  18.4 g/l

Key value for chemical safety assessment

Water solubility:

18.4 g/L

at the temperature of:

20 °C

Additional information

The determination of the water solubility of 2-(2’-Vinyloxy ethoxy) ethyl acrylate was performed according to the EEC Directive 92/69, A.6 ”Water Solubility” (1992) and the OECD guideline No. 105, ”Water Solubility” (1995) using the flask shake method.

The water solubility of 2-(2’-Vinyloxy ethoxy) ethyl acrylate at 20°C was determined to be 18.4 g/L.