Registration Dossier
Registration Dossier
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EC number: 440-740-5 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 MAR 2000 - 21 MAR 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- EG-Guidline 92/69/EEC A.8.
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- > 4.7
- Temp.:
- 40 °C
- Remarks on result:
- other: not further information available
- Details on results:
- Determination of the dead time t0:
Regression: tR(nc + 1) = a + b tR(nc)
Parameters: a = -1.1334 b = 1.4767 r^2 = 0.9999
Dead time: t0 = a / (1 - b)
t0 = 2.377 min
Calibration data:
Regresssion: log Pow = a + b log k'
Parameters: a = 2.992; b = 3.064; r^2 = 0.9242
log Pow of the test substance
1st injection: tR = 12.89 min
2nd injection: tR = 12.90 min
mean: tR = 12.90 min
k' = 4.42
log k' = 0.65
log Pow = 5.0 - Conclusions:
- The logPow was found to be > 4.7 (Pow > 50119).
- Executive summary:
The partition coefficient n-octanol/water of the test substance was determined according to the "HPLC method" described in EG-Guideline 92/69/EEC A.8., following GLP.
The log Pow was found to be > 4.7 (Pow > 50119), referred to log Pow of the standard fluoranthene. The calculated log Pow is 5.0 which is outside the calibration area.
Reference
Description of key information
The partition coefficient n-octanol/water of the test substance was determined according to the "HPLC method" described in EG-Guideline 92/69/EEC A.8., following GLP.
The logPow was found to be > 4.7 (Pow > 50119), referred to log Pow of the standard fluoranthene. The calculated log Pow is 5.0 which is outside the calibration area.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5
- at the temperature of:
- 40 °C
Additional information
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