Registration Dossier
Registration Dossier
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EC number: 418-220-4 | CAS number: - RED JB 747
Endpoint summary
Administrative data
Description of key information
Skin Sens 1B
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
To assess the allergenic potential of test item in albino guinea pigs the Maximization-Test of B. Magnusson and A.M. Kligman (1969) was used. The study was conducted according to internationally accepted guidelines (OECD 406).
In the study it was found that 70 and 60 % of the animals gave a positive response at the 24 and 48 hour time points respectively following challenge with the highest non-irritating concentration of 25 % test item.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In this study it was found that 70 and 60 % of the animals gave a positive response at the 24 and 48 hour time points respectively followlng challenge wlth an induction perfomed at 5 % of test article in bi-distrilled water.
According to CLP Regulation (EC 1272/2008) section 3.4.2, the test substance shall be classified as skin sensitisers sub-category 1B, in Guinea pig maximisation test positive responses have been recorded in more than 30 % of population, responding an intradermal induction dose higher than 1 %.
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