Registration Dossier
Registration Dossier
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EC number: 310-080-1 | CAS number: 102242-49-9 The complex residue resulting from the vacuum distillation of C6-24 fatty alcohols which is derived from hydrogenation of C6-24 fatty acids methyl esters. It consists predominantly of satd. fatty alcohols having carbon numbers greater than C18, dimerization products, and long chain esters having carbon numbers greater than C32 and boils at > 250°C (482°F) at 10 torr.
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The skin sensitising potential of the test substance was investigated in a study according to OECD test guideline 429 under GLP. Concentrations of 10, 25 and 50% were applied topically (open) on the dorsal side of the ears of NMRI six mice each. This application was repeated twice (24 and 48h after the first application). On day 4, after humane killing on the mice, the lymph nodes were removed and the cells suspended. In addition to the primary endpoint of cell count (expressed as stimulation index), ear thickness and weight and lymph node weight were measured. As the stimulation index for all three tested concentration was clearly below 1.4, i.e. the threshold for a positive result, the test substance is not considered to be a skin sensitiser.
Migrated from Short description of key information:
Based on the results of the only available (and reliable) study (LLNA), the test substance is not considered to be a skin sensitiser.
Justification for classification or non-classification
As the test substance did not induce any skin sensitisation, it is not classified regarding this health effect.
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