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EC number: 310-080-1 | CAS number: 102242-49-9 The complex residue resulting from the vacuum distillation of C6-24 fatty alcohols which is derived from hydrogenation of C6-24 fatty acids methyl esters. It consists predominantly of satd. fatty alcohols having carbon numbers greater than C18, dimerization products, and long chain esters having carbon numbers greater than C32 and boils at > 250°C (482°F) at 10 torr.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No study is available in which the toxicokinetic properties (distribution, metabolism, elimination) of the substance were specifically investigated. In fact, such a study is hardly feasible due to the complex UVCB-composition of the substance.
The expected toxicokinetic behaviour is derived from the physicochemical properties, the results from the available toxicological studies and the available literature following the information given in guidance document 7c.
The substance is a solid (at 20°C) with a water solubility of <0.05 mg/L (20°C) and a lipophilic character (log Pow >5.7). It has a very low vapour pressure of <0.014 P (20°C) and consequently a very low volatility. It is not surface active.
Oral and GI absorption:
Substance is not soluble in water and in GI fluids. It will not easily pass through aqueous pores or epithelial barriers. The substance or parts of the substance may be taken up by micellular solubilisation. The limited systemic toxicity data on representative constituents of the substance furthermore does not indicate absorption through the GI tract. This is supported by experimentally determined poor gastrointestinal absorption of the main constituent octadecan-1-ol.
Inhalative absorption:
The substance does not easily pass through aqueous pores or epithelial barriers. Absorption via the lung is therefore not assumed to occur to a significant extent.
Dermal absorption:
Due to the physico-chemical information, the substance can be assumed to be absorbed via the skin.
Distribution:
Because of the very low solubility, poor distribution can be assumed. Fatty alcohols may enter lipid biosynthesis, but fatty acids derived from fatty alcohols will be indistinguishable from the lipids derived from other sources.
Accumulative potential:
Based on the PC information the main site of accumulation is assumed to be the adipose tissue as well as skin. No accumulation in bone or in lung is predicted. There is only limited potential for retention or bioaccumulation for long chain alcohols, i.e. the parent alcohols and their biotransformation products.
Metabolism:
Linear or essentially linear hydrocarbon chains are readily oxidised metabolically. Long chained alcohols, which sum up to about 70%of the substance, are generally highly efficiently metabolised either by oxidation to the corresponding carboxylic acids, followed by a stepwise elimination of C2 units in the mitochondrial β-oxidation process. The end product acetyl CoA enters the citric cycle and is furthermore metabolised to CO2 and water. This process may be preceeded by a ω or ω-1 oxidation. Alternatively, they might be used in lipid biosynthesis. Consequently, there is limited potential for retention or bioaccumulation for the parent alcohols and their biotransformation products.
The wax ester components of the substance are assumed to be metabolised to alcohols and fatty acids, both of which are further metabolised as described above.
Reactivity:Available studies on genotoxicity were negative, i.e. there is no indication of a reactivity of the test substance or its metabolites under the test conditions.
Excretion:
The metabolic end products carbon dioxide and water are excreted via urine or exhaled.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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