Registration Dossier
Registration Dossier
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EC number: 309-849-4 | CAS number: 101316-44-3
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
PNEC derivation not required for a transported isolated intermediate. Furthermore, acetophenone [CAS no. 98-86-2] and phenol [CAS no. 108-95-2] dominate with > 50 % (w/w) and < 20 % (w/w) in Acetophenone fraction [CAS no. 101316 -44 -3], which are not classified as to environmental hazards.
However, constituents other than acetophenone and phenol trigger environmental classification (see Section 2).
Conclusion on classification
ACETOPHENONE
Aquatic environment classification
Acetophenone proved to be readily biodegradable (64.7% biodegradation after 14 d).
The lowest acute EC/LC50 value in aquatic tests is the EC50 of 86.4 mg/L for algae.
Due to the fact that acetophenone is proven to be readily biodegradable and its log Kow of 1.65 is low, the substance is not classified as dangerous/hazardous for the environment according to Directive 67/548/EEC and according to the Regulation (EC) 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP Regulation):
Lowest reliable L(EC)50 value: 86.4 mg/L algae
Ready biodegradable yes
log Pow < 3
Special concern: no
According to 67/548/EEC Annex 1: not classified
According to GHS:
Hazardous to the environment not classified, no hazard statement
Reason for classification: L(E)C50: 10 – 100 mg/L; readily biodegradable, log Pow<4
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PHENOL
Aquatic environment classification
Due to the high degradation rates within a period of < 10 days phenol is ready biodegradable in waste water, freshwater, sea water, and at anaerobic conditions with inoculum created from activated sludge.
The lowest acute EC/LC50 value in aquatic tests is the EC50 of 3.1 mg/L, based on measured initial concentrations, obtained in a static 48-h acute toxicity test with Ceriodaphnia dubia (Oris et al. 1991).
Due to the ready biodegradability of phenol and its low log Pow, the substance is not classified as dangerous/hazardous for the environment according to Directive 67/548/EEC and according to the Regulation (EC) 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP Regulation):
Lowest reliable L(EC)50 value: 3.1 mg/L Daphnids
Ready biodegradable yes
log Pow < 3
Special concern: no
According to 67/548/EEC Annex 1: not classified
According to GHS:
Hazardous to the environment not classified, no hazard statement
Reason for classification: L(E)C50 1-10 mg/L; readily biodegradable, log Pow<4
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