Registration Dossier
Registration Dossier
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EC number: 308-121-3 | CAS number: 97862-72-1
Endpoint summary
Administrative data
Description of key information
Albino rats in groups of ten (5M:5F), weighing between 150 and 300 g, were dosed with 5000 mg/kg lanolin fatty acids once using an oral method, and observed for fourteen days (Lewis 1977). The LD50 of the test material has been determined to be greater than 5 g/kg/bw.
A study to determine the oral toxicity of Lanolin alcohols was conducted following the OECD Guidelne 401 and EC guideline B1 (Leuschner 2001). Under the test conditions (a single oral dose of the test material at 2000 mg/kg bw) to rats revealed no toxic symptoms. The LD50 is > 2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- No study on the ester of lanolin alcohols and fatty acids is available, as the substance is expected to be hydrolysed by esterases, the acute toxicity of the hydrolysis products lanolin alcohols and lanolin fatty esters is representative for the acute toxicity of the substance
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No studies on the ester of lanolin alcohols and fatty acids are available, as the substance is expected to be hydrolysed by esterases, the acute toxicity of the hydrolysis products lanolin alcohols and lanolin fatty esters is representative for the acute toxicity of the substance
Justification for classification or non-classification
Based on the available information, the substance does not need to be classified for acute toxicity according to Regulation (EC) No 1272/2008 (CLP).
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