Registration Dossier
Registration Dossier
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EC number: 306-361-3 | CAS number: 97158-31-1
Endpoint summary
Administrative data
Description of key information
rat oral LD50 > 2000 mg/kg
dermal: data waiving
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 02, 1994 - May 30, 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1987
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- none
- Clinical signs:
- uncoordinated movements in all animals 4 hours after dosing
- Body weight:
- no effect
- Gross pathology:
- no abnormalities
- Other findings:
- none
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- rat oral LD50 > 2000 mg/kg (both sex)
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- inhalation exposure is not likely taking into account the vapor pressure of the substnace and the conditions of use in the workplace, e.g. the likelihood of exposure with an aerosol.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- A dermal LD50 study does not need to be conducted as the result of an acute oral toxicity study does not meet the criteria for classification as well as an primary skin irritation study did not meet the criteria for classification. Thus, no systemic toxicity is predicted after single dermal exposure (the rat dermal LD50 is most probably >2000 mg/kg bw).
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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