Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 297-049-5 | CAS number: 93333-79-0 The residuum from the burning of a combination of plants.
Endpoint summary
Administrative data
Description of key information
Repeated oral dose toxicity was performed in accordance with the method:Method B.26 Sub-Chronic Oral Toxicity Test: Repeated Dose 90-day Oral Toxicity Study in Rodents, Council Regulation (EC) No. 440/2008, Published in O.J. L142, 2008
GLP study
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 400 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
The value of NOAEL (No Observed Adverse
Effect Level) for males and females is 400 mg/kg/day. The value was
established on the basis of haematology, urinalysis and
histopathological examination.
No studies on repeated dose dermal toxicity and repeated dose inhalation toxicity of test substance are available.
Justification for classification or non-classification
The data from Study No. 3/10/8: Ashes (residues) – Biomass Combustion-Repeated Dose 90-day Oral Toxicity Study are of acceptable quality for classification of substances for STOT RE.
The values of NOAEL was used in weight of evidence approach based on a comparison with classification criteria.
The Guidance Values (dose/concentration) for STOT RE Category 1 is C ≤ 10 mg/kg body weight/day, the Value Ranges (dose/concentration) for STOT RE Category 2 is 10 < C ≤ 100 mg/kg body weight/day for oral route exposure (Regulation (EC) No.1272/2008).
The lowest value of NOAEL (400 mg/kg body weight/day) is above the Guidance Values and Range (C).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
