Registration Dossier
Registration Dossier
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EC number: 290-335-0 | CAS number: 90131-24-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Spilanthes acmella, Compositae.
Boiling point
Administrative data
Link to relevant study record(s)
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 06 to 3 March 2018.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The study was conducted according to an internationally recognised method, and under GLP. The test substance is adequately characterised. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Version / remarks:
- 2008
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Inspected on 4,5 and 6 July 2016/ Signed on 10 January 2017
- Type of method:
- differential scanning calorimetry
- Key result
- Atm. press.:
- 101.3 kPa
- Decomposition:
- yes
- Decomp. temp.:
- ca. 267.1 °C
- Conclusions:
- The decomposition of the substance is determined at 267.1°C. No boiling point can be determined.
- Executive summary:
The study was performed in order to determine the boiling point of test item according to OECD 103, resp. EU A.2, using the DSC method.
An exothermic peak was observed at 267.1°C (mean of 267.0 °C for the first determination and 267.1 °C for the second determination) corresponds to the degradation of the substance and a mass loss was observed on the TG curve.An endothermic peak was determined at 383.6 °C (mean of 383.6 °C for the first determination and 383.6 °C for the second determination) and a mass loss was observed on the TG curve, showing that almost all the substance was evaporated (including potential degradation compounds) at the end of the study.
Reference
Results
All the raw data (calibration, pre-test and main tests) is in the experimental report.
Pre-study
The measurement was stopped at 380°C.
Temperature program:
Step |
Initial temperature (°C) |
Final Temperature (°C) |
Heating rate (°C/min) |
Duration (min) |
Furnace atmosphere |
Rate* (mL/min) |
Liquid nitrogen cooling |
1 |
-120 |
380 |
10 |
50 |
He |
60 |
NO |
2 |
380 |
280 |
10 |
10 |
He |
60 |
YES |
3 |
280 |
280 |
0 |
10 |
He |
60 |
NO |
4 |
380 |
550 |
10 |
17 |
He |
60 |
NO |
Test 1:
An exothermic peak was observed at 267.0 °C corresponds to the degradation of the substance and mass loss was observed on the TG curve.
An endothermic peak was observed at 383.6 °C and a corresponding mass loss is observed on the TG curve, showing that all the substance was evaporated (including potential degradation compounds)at the end of the study.
The crucible was visually checked after the determination: By opening the crucible, no test item left in the crucible.
Atmospheric pressure: 974.0 hPa.
Test 2:
An exothermic peak was observed at 267.1 °C corresponds to the degradation of the substance and mass loss was observed on the TG curve.
An endothermic peak was observed at 383.6 °C and a corresponding mass loss is observed on the TG curve, showing that all the substance was evaporated (including potential degradation compounds) at the end of the study.
The crucible was visually checked after the determination: By opening the crucible, no test item left in the crucible.
Atmospheric pressure: 974.0 hPa.
Remark: A peak corresponding to a glass transition was observed only during this determination.
Conclusion
An exothermic peak was observed at 267.1°C (mean of 267.0 °C for the first determination and 267.1 °C for the second determination) corresponds to the degradation of the substance and a mass loss was observed on the TG curve. An endothermic peak was determined at 383.6 °C (mean of 383.6 °C for the first determination and 383.6 °C for the second determination) and a mass loss was observed on the TG curve, showing that almost all the substance was evaporated (including potential degradation compounds) at the end of the study.
Description of key information
The decomposition of the substance is determined at 267.1°C. No boiling point can be determined.
Key value for chemical safety assessment
Additional information
A fully reliable experimental study, conducted according to OECD 102/ EU A1 guideline is available.
It is considered as a key study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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