Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 290-058-5 | CAS number: 90063-97-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Mentha arvensis, Labiatae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Estimation based on calculations by validated QSAR model.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- NCSs, consisting of a number of constituents, do not have one single BCF value but a range of BCF values. BCF tests are not adapted to such complex UVCBs such as the NCSs, because of analytical monitoring issues (existing test protocols have been developed for single molecules which are preferably radio –labelled). Therefore a constituent approach is followed.
The range of BCF can be based on calculated or measured values of the individual constituents. Very few measured BCF values are available for the individual constituents. However, for all constituents, calculated BCF values can be derived by QSAR from log Kow.
A drawback of every QSAR is that biotransformation is not included. The calculation method for BCF is generally realistic for the actual value, unless biotransformation occurs. When a substance is subject to biotransformation, the actual BCF will be lower than the calculated BCF. Thus, BCF calculations by QSAR are a worst case approach.
The TGD provides the following information about the different QSAR models available for estimating BCF from log Kow: “Among the QSAR models based on the correlation between BCF and Kow, Meylan et al. (1999) compared their proposed fragment-based approach with a linear (Veith & Kosian, 1983) and bilinear (Bintein et al., 1993) model, using a data set of 610 non-ionic compounds. The fragment method provided a considerably better fit to the data set of recommended BCF values than the other two methods, as shown by the higher R2 value, but more importantly, a much lower SD and ME.” This supports the use of the more recently developed model by Meylan et al (1999) instead of the older model according to Veith et al (1979). The Meylan QSAR is used by the EPIWIN program and is validated. Attention is paid that each constituent falls within the applicability domain of the QSAR. - GLP compliance:
- no
- Key result
- Type:
- other: log BCF
- Value:
- 1.47 - 4.282 dimensionless
- Basis:
- whole body w.w.
- Calculation basis:
- other: QSAR model based on log Kow
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The range of log BCF values for the known constituents of cornmint oil is 1.47 - 4.282.
- Executive summary:
The log BCF values of known cornmint oil constituents were estimated using the QSAR BCFBAF v 3.00. Log Kow estimates were calculated using the corresponding log Kow value estimated by KOWWIN (see chapter 4.7)
The range of log BCF values for the known constituents of cornmint oil was found to be 1.47 - 4.282. 62% of the NCS has a log BCF of 1.679 - 1.772 (menthone + L-menthol).
Reference
Estimated log BCF values for the known constituents of cornmint oil:
Substance | CAS | Estimated log BCF |
L-menthol | 2216-51-5 | 1.772 |
Menthone | 89-80-5 | 1.679 |
L-limonene | 5989-54-8 | 2.557 |
alpha pinene | 7785-70-8 | 2.597 |
betapinene | 127-91-3 | 2.412 |
Iso-menthone | 491-07-6 | 1.679 |
neo-menthol | 2216-52-6 | 1.772 |
Menthyl Acetate | 16409-45-3 | 2.306 |
Piperitone | 89-81-6 | 1.547 |
Pulegone | 89-82-7 | 1.699 |
Iso-Pulegol | 89-79-2 | 1.893 |
Germacrene-D | 37839-63-7 | 4.282 |
Neo-iso pulegol | 89-79-2 | 1.893 |
1,8-cineole | 470-82-6 | 1.475 |
octan-3-ol | 589-98-0 | 1.47 |
sabinene | 3387-41-5 | 2.761 |
Myrcene | 123-35-3 | 2.418 |
Neo-iso menthol | 89-78-1 | 1.772 |
Beta-caryophyllene | 87-44-5 | 3.825 |
Description of key information
The range of log BCF values for the known constituents of cornmint oil was found to be 1.47 - 4.282 (BCF 30 - 19143).
Key value for chemical safety assessment
Additional information
The log BCF values of known cornmint oil constituents were estimated using the QSAR BCFBAF v 3.00. Log Kow estimates were calculated using the corresponding log Kow value estimated by KOWWIN (see chapter 4.7).
The range of log BCF values for the known constituents of peppermint oil was found to be 1.47 - 4.282 (BCF 30 – 19143). 62% of the NCS has a log BCF of 1.679 - 1.772 (BCF 48 – 59, menthone + L-menthol).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.