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EC number: 289-550-2 | CAS number: 89923-62-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: AFNOR NF T-90 301 (Avril 1974)
- Deviations:
- not specified
- GLP compliance:
- no
- Specific details on test material used for the study:
- None
- Analytical monitoring:
- no
- Details on sampling:
- None
- Vehicle:
- no
- Details on test solutions:
- None
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna straus
- Source: I.R.CH.A
- Length at study initiation: 560-800 micrometer - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Post exposure observation period:
- None
- Hardness:
- N/A
- Test temperature:
- 20 ± 2 °C
- pH:
- 8.41
- Dissolved oxygen:
- 6.5 mg O2/L
- Salinity:
- freshwater used
- Nominal and measured concentrations:
- Nominal concentrations:
- Preliminary test: 8, 10, 13, 17, 22, 29 mg/L.
- Main test: 17, 22, 29, 37, 48 mg/L. - Details on test conditions:
- TEST SYSTEM:
- No. of organisms per vessel: 5 daphnids
- No. of vessels per concentration (replicates): 4 replicates
- No. of vessels per control (replicates): 4 replicates
- No. of vessels per vehicle control (replicates): No data
TEST MEDIUM / WATER PARAMETERS
preparation of dilution water:
- NaHCO3 : 0.200 g
- CaCl2 or CaCl2 H2O: 0.224 g
- K2SO4: 0.026 g
- Bidistilled water until 1000 ml
Dissolved oxygen in dilution water should be greater than 80%. If it is not the case, aerate the solution until the concentration of dissolved oxygen is achieved.
OTHER TEST CONDITIONS
- Adjustment of pH: pH should be at 8.0 ± 0.2. If not, the pH will be adjusted using Chloridic acid or Sodium hydroxide. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate (K2Cr2O7)
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 17.2 - < 33 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 22.4 - < 27.3
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: corrected value
- Details on results:
- - Behavioural abnormalities: No
- Observations on body length and weight: No
- Other biological observations: No
- Mortality of control: 0% immobility in daphnia control.
- Other adverse effects control: No
- Abnormal responses: No
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: No - Results with reference substance (positive control):
- IC50 (24 hours) with Potassium dichromate is determined to be: 0.92-1.45 mg/l.
In general the IC50 for 24 h of the reference substance is around 1.2 mg/L. - Reported statistics and error estimates:
- None
- Validity criteria fulfilled:
- yes
- Conclusions:
- The IC50 of FAT 20242/B in this acute immobilisation test (24 hours exposure time), was determined to be between 17.2- 33 mg/L.
The corrected value of IC50 (exposure time 24 hours) was found to be 22.4 - 27.3 mg/l thus 25 mg/L. - Executive summary:
FAT 20242/B was tested to determine the 24 hr IC50 to Daphnia magna straus. The experiment was performed according to the AFNOR NF T-90 301 (April 1974) guideline, (Determination of the mobility inhibition to Daphnia magna straus).
A preliminary experiment was performed to determine the concentration range for the main test. Nominal concentrations:
- Preliminary test: 8,10, 13, 17, 22, 29 mg/L.
- Main test: 17, 22, 29, 37, 48 mg/L.
In parallel, the reference substance, Potassium dichromate (K2Cr2O7) was also tested to Daphnia magna.
IC50 (24 hours) with Potassium dichromate is determined to be: 0.92 - 1.45 mg/l.
The IC50 of FAT 20242/B in this acute immobilisation test (24 hours exposure time), was determined to be between 17.2 - 33 mg/L.
The corrected value of IC 50 (exposure time 24 hours) was found to be 22.4 - 27.3 mg/l thus 25 mg/L.
Reference
None
Description of key information
The EC50 of FAT 20242/B in this acute immobilisation test (24 hours exposure time), was determined to be between 17.2- 33 mg/L. The corrected value of EC50 (exposure time 24 hours) was found to be 22.4-27.3 mg/l thus 25 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 25 mg/L
Additional information
A key study on FAT 20242/B was conducted to determine the 24 hr IC50 value to Daphnia magna. The experiment was performed according to the AFNOR NF T-90 301 (avril 1974) guideline, (Determination of the mobility inhibition to Daphnia magna straus). A preliminary experiment was performed to determine the concentration range for the main test. In the main study the concentrations tested were 17, 22, 29, 37, 48 mg/L.
In parallel, the reference substance, Potassium dichromate (K2Cr2O7) was also tested to Daphnia magna. IC50 (24 hours) with Potassium dichromate was determined to be: 0.92-1.45 mg/l.
The IC50 of FAT 20242/B in this acute immobilisation test (24 hours exposure time), was determined to be between 17.2- 33 mg/L.
The corrected value of IC 50 (exposure time 24 hours) was found to be 22.4-27.3 mg/l thus 25 mg/L.
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