Registration Dossier
Registration Dossier
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EC number: 289-124-6 | CAS number: 86014-76-8
Endpoint summary
Administrative data
Description of key information
OECD406, GMPT, not skin sensitizer
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The analogue substance 2 was tested for its sensitizing effect on the skin of the guinea pig in the Maximization Test based on the method of Magnusson and Kligman according to OECD guideline 406 (BASF 1988). After the challenge application, no cutaneous reactions were observed in the animals of the control and test groups at the 24-hour and 48-hour readings.
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008) the following classifications apply:
skin sensitizer Cat 1A, with GPMT:
≥ 30 % is responsive to ≤ 0,1 % of the intradermal induction dose or
> 60 % is responsive to > 0,1 %- ≤ 1 % of the intradermal induction dose
skin sensitizer Cat 1B, with GPMT
≥ 30 % to < 60 % is responsive to > 0,1 % - ≤ 1 % of the intradermal induction dose or,
≥ 30 % is responsive to > 1 % of the intradermal induction dose
Based on the results of the skin sensitization test (GPMT) the substance is not classified as skin sensitizer
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