Registration Dossier
Registration Dossier
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EC number: 287-634-3 | CAS number: 85566-24-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC10 (3 h) > 1000 mg/L for activated sludge microorganisms (OECD 209)
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of Fatty acids,
C14-18, C14-18-alkyl esters (CAS 85566-24-1) to activated sludge
microorganisms are available, in accordance to Regulation (EC) No
1907/2006 Annex XI, 1.5 a read-across to the structurally related source
substances Fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) was
conducted. The source substance is representative to evaluate the
long-term toxicity of the target substance to activated sludge
microorganisms. The target substance is characterized as an ester of
mainly C14 fatty acid/C14 alcohol, C16 fatty acid/C14 alcohol and C16
fatty acid/C16 alcohol. The source substance is structurally very
similar to the target substance. Fatty acids, C8-10, C12-18-alkyl esters
(CAS 95912-86-0) is a UVCB substance consisting of mainly C8-C10 fatty
acids esterified with C12-C14 alcohol. This read-across is justified in
detail in the overall summary (IUCLID Section 6.1) and within the
analogue justification in IUCLID Section 13. In this case of
read-across, the best suited (highest degree of structural similarity,
nearest physico-chemical properties) read-across substance was used for
the assessment.
The study with the read-across substance Fatty acids, C8 - 10, C12 -
18-alkyl esters (CAS 95912-86-0) was performed according to OECD 209
under GLP conditions (Hammer, 2013). Activated sludge microorganisms
were exposed to the test substance up to a nominal concentration of 1000
mg/L. No effects were observed based on the respiration rate after 3 h
of incubation resulting in an EC10 (3 h) of > 1000 mg/L. An increase of
respiration was recorded in all treatments compared to the control
values.
Based on the available results from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Fatty acids, C14-18, C14-18-alkyl esters will not exhibit effects on activated sludge microorganisms and does not inhibit the microbiological process of degradation in sewage treatment plants.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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