Saccharomyces cerevisiae, ext.

Partition coefficient

Administrative data

Endpoint:

partition coefficient

Type of information:

other: Expert statement

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

Determination of the partition coeffecient for the yeast Saccharomyces Cerevisiae is not scientifically feasible.

Data source

Reference

Reference Type:

other:

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Qualifier:

no guideline required

Guideline:

other: The experimental log Kow determination is technically not feasible. The main reasons are developed in the attached report concerning each available method (AU A.8, OECD 107), (EU A.8, OECD 117), and (OECD 123).

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Saccharomyces cerevisiae, ext.

EC Number:

283-294-5

EC Name:

Saccharomyces cerevisiae, ext.

Cas Number:

84604-16-0

Molecular formula:

Not applicable as the substance is an UVCB

IUPAC Name:

Yeast extract, Saccharomyces cerevisiae

Details on test material:

- Name of test material (as cited in study report): Saccharomyces cerevisiae, Extract (Springer 0204/0-LQ-L)
- Molecular formula: -
- Molecular weight: -
- Substance type: Brown liquid
- Physical state: liquid
- Analytical purity: 48.0 – 52.0% (dry matter)
- Impurities (identity and concentrations): -
- Composition of test material, percentage of components: -
- Isomers composition: -
- Purity test date: -
- Lot/batch No.: 081000310
- Expiration date of the lot/batch: 30 April 2012
- Stability under test conditions: Stable
- Storage condition of test material: At room temperature in the dark
- Other: -

Study design

Analytical method:

not specified

other: Statement supporting that the partition coefficient test for the yeast extract is scientifically not feasible

Results and discussion

Partition coefficient

Key result

Type:

log Pow

Partition coefficient:

> 0

Temp.:

0 °C

pH:

0

Remarks on result:

not measured/tested

Details on results:

Due to the complex composition of the substance “Saccharomyces cerevisiae extract”, it is not feasible to determine its partition coefficient experimentally. The shake flask method, the HPLC method and the slowstirring method are not applicable to this substance. QSARs calculations are not possible due to the complex composition and the unknown precise structure of the constituents. Even the estimation of log Kow based on the solubility in water and in n-octanol is technically not feasible. A rough estimated single log Kow value or a broad range of log Kow values for “Saccharomyces cerevisiae extract” would not contribute to hazard assessment or to classification. Indeed, the constituents of this soluble fraction are very different substances with different physical-chemical properties and probably the log Kow value of the organic constituents will cover a broad range of log Kow values. However due to the high solubility of these components (20% at 50°C pH 5 to 5.5), the log Kow must be low, and therefore it is concluded that there is no concern on bioaccumulation.

Any other information on results incl. tables

The test substance is a complex mixture of organic components in water. Each component will have its own partition coefficient. Therefore the partition coefficient of the test substance cannot be determined.

Applicant's summary and conclusion

Conclusions:

Due to the complex composition of the substance “Saccharomyces cerevisiae extract”, it is not feasible to determine its partition coefficient experimentally.

Executive summary:

Due to the complex composition of the substance “Saccharomyces cerevisiae extract”, it is not feasible to determine its partition coefficient experimentally. The shake flask method, the HPLC method and the slowstirring method are not applicable to this substance. QSARs calculations are not possible due to the complex composition and the unknown precise structure of the constituents. Even the estimation of log Kow based on the solubility in water and in n-octanol is technically not feasible. A rough estimated single log Kow value or a broad range of log Kow values for “Saccharomyces cerevisiae extract” would not contribute to hazard assessment or to classification. Indeed, the constituents of this soluble fraction are very different substances with different physical-chemical properties and probably the log Kow value of the organic constituents will cover a broad range of log Kow values. However due to the high solubility of these components (20% at 50°C pH 5 to 5.5), the log Kow must be low, and therefore it is concluded that there is no concern on bioaccumulation.