Registration Dossier
Registration Dossier
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EC number: 278-145-6 | CAS number: 75234-41-2
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The test item showed no transformation at pH 9 at the environmental typical temperature of 20 °C.
At pH 4 and 7 the test item was found to be stable in the preliminary test at 50 °C.
Key value for chemical safety assessment
Additional information
Hydrolysis as a function of pH was determined according to OECD Guideline No. 111 and Council Regulation (EC) No. 440/2008, Method C.7 for the test item atDr.U.Noack-Laboratorien, 31157 Sarstedt, Germany.
Analyses of the test item were performed viahigh performance liquid chromatography with diode array UV detection (HPLC-DAD)on a reversed phase column using an external standard. The method was validated with satisfactory results in regard to linearity, accuracy, precision and specificity.
For pH 4, 7 and 9 a 5 day (preliminary) testing at 50 °C was performed. During this testing hydrolysis (more than 10 % reduction of the test item) was only observed at pH 9 and therefore for pH 9 the advanced testing was performed.
The advanced testing was conducted with a test item concentration of 10 mg/L in buffer solutions of pH 9 at a temperature of 20 °C for 30 days. For pH 9 samples were taken at test start (0 h) and 10 spaced points until end. Buffer solutions were analysed at test start and test end and there was no analytical interference with the test item. No Hydrolysis was observed at the tested condition.
For the test itemno hydrolysiswas observed at the tested concentration.
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