Registration Dossier
Registration Dossier
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EC number: 277-091-0 | CAS number: 72928-81-5
Endpoint summary
Administrative data
Description of key information
LD50(oral) > 5000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No information is available on the substance itself, i.e. Solvent Red 122. However, a study on a read across substance, i.e. Similar Substance 01, was available and used for the assessment. A detailed description of the read across process was attached in section 13.
Acute oral toxicity to rats of test substance was tested at a concentration of 1000 and 5000 mg/kg. No mortality was recorded and symptoms (dyspnoea, curved position and ruffled fur) disappeared within the 14 -day observation period. Thus, a LD0 of 5000 mg/kg was established.
Justification for classification or non-classification
According to the CLP Regulation (EC 1272/2008), substances can be allocated to one of four toxicity categories based on acute toxicity by the oral, dermal or inhalation route according to numeric criteria. Acute toxicity values are expressed as (approximate) LD50 (oral, dermal) or LC50 (inhalation) values or as acute toxicity estimates (ATE).
The oral LD50 value was established to be greater than 5000 mg/kg body weight, therefore the test substance is above the classification threshold for acute oral toxicity (Category 4: 300 < ATE ≤ 2000 mg/kg).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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