Registration Dossier
Registration Dossier
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EC number: 273-521-6 | CAS number: 68988-22-7 A complex residuum from the distillation of products from the manufacture of dimethyl terephthalate by air oxidation and esterification of p-xylene. It consists of polyphenyl polyesters.
Endpoint summary
Administrative data
Description of key information
Not irritating to skin according to a guideline study (OECD TG 404) and not irritating to eyes according to a guideline study (OECD TG 405).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritancy of the test substance was determined in a guideline study (OECD TG 404) in rabbits. The test substance was found to be not irritating. Skin corrosivity of the test substance was determined in vitro in a guideline study (EU B.40). The test substance was found to be not corrosive.
Eye irritancy of the test substance was determined in a guideline study (OECD TG 405) in rabbits. The test substance was found to be not irritating to eyes in this study, which is decisive for classification. Eye irritancy of the test substance was also determined in vitro according to a draft guideline (OECD, Draft proposal for a new guideline: "Bovine Corneal Opacity and Permeability (BCOP) Test Method for Identifying Ocular Corrosives and Severe Irritants). There, the test substance was found to be slightly irritating, which is not decisive for classification.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
The classification criteria for skin or eye irritation according to Regulation (EC) No. 1272/2008 are not met.
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