Registration Dossier
Registration Dossier
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EC number: 270-790-1 | CAS number: 68478-10-4 A complex combination of hydrocarbons obtained by the distillation of debenzenized light steam-cracked naphtha. It consists predominantly of cyclic olefinic and aromatic hydrocarbons having carbon numbers predominantly in the range of C8 through C16 and boiling in the range of approximately 130°C to 300°C (226°F to 572°F).
Neurotoxicity
Administrative data
Description of key information
There are no specific neurotoxicity data on any of the streams within the Resin Oils and Cyclic Dienes category. Of the specific components toluene and styrene are recognised as having neurotoxic activity. These effects are discussed in the section on repeated dose toxicity (5.6.3).
Key value for chemical safety assessment
Additional information
Toluene exposure can produce central nervous system pathology in animals after high oral doses. In humans neuropsychological effects have been reported, particularly when exposures are not well controlled. There was no evidence that long-term exposure to toluene at 26 ppm for 21 years had any effects on cognitive function (Seeber et al, 2004). Inhalation exposure to styrene in animals produces impaired nerve conduction velocity.
Justification for classification or non-classification
See section 5.6 for overall classification for repeated dose toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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