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Diss Factsheets
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EC number: 267-184-4 | CAS number: 67801-64-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
One valid enhanced ready and two ready studies have been performed on the test substance.
Two ready studies (MITI 1 and Closed bottle test) failed to find significant biodegradation within 28 days therefore a further enhanced ready test was performed on the test substance using an OECD 301F (Hammesfahr, 2016) over a period of 60 days. The biodegradation was followed by the oxygen uptake of the microorganisms during exposure with a test item loading rate of 103.5 mg/L corresponding to an oxygen demand of about 253.8 mg/L (ThODNH4). As a reference item sodium benzoate (103.3 mg/L corresponding to an oxygen demand of about 172.1 mg/L(ThODNH4)) was tested simultaneously under the same conditions as the test item. It functioned as a procedure control. Degradation rate of test item calculated by the oxygen consumption of the aerobic activated sludge microorganisms after 60 days of incubation.
All validity criteria were met. Degradation of the positive control was 76% after 14 and 28 days and to 78% after 60 days of incubation, thus confirming the suitability of the aerobic activated sludge inoculum used.
The degradation rate of the test substance did not reach 60% within 28 days. Therefore, it is considered to be not readily biodegradable. The degradation rate did not reach 60% after 60 days although some inhibition of basal respiration rate was observed in the test solution flasks compared to the control suggesting potential toxicity and increase in lag time. From day 30, mineralisation started to occur and remained linear until the end of the study where 32% biodegradation was recorded without a plateau being reached.
While non-Persistency of the degradation products cannot be assumed based on this evidence, 32% degradation within 60 days is sufficient to assume 100% primary biodegradation of the test substance as well as at least partial degradation of some of the metabolites.
In a third study using an OECD 301D method no biodegradation was observed over 28 days however, despite the reference reaching the required threshold, very low basal respiration was observed over the study in the controls suggesting low microbial activity for an OECD 301D so the lack of biodegradation observed in this study should be considered only as supporting evidence that the test substance does not rapidly degrade.
The substance may be considered inherently biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.