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EC number: 260-280-7 | CAS number: 56602-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 February 2016 to 21 April 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- Buffer solutions were prepared as follows:
pH 4:
0.2M aqueous glacial acetic acid (102.5 mL) was mixed with 0.2M aqueous sodium acetate (22.5 mL) and diluted to volume (250 mL) with purified water. The pH was measured and confirmed to be 4.0 ± 0.05.
pH 7:
0.1M aqueous tris(hydroxymethyl)aminomethane (125 mL) was mixed with 0.1M hydrochloric acid (116.5 mL). The pH was measured and confirmed to be 7.0 ± 0.05.
pH 9:
0.1M aqueous tris(hydroxymethyl)aminomethane (250 mL) was mixed with 0.1M hydrochloric acid (28.5 mL). The pH was adjusted to 9.0 ± 0.05 with further 0.1M hydrochloric acid. - Details on test conditions:
- PRELIMINARY TEST
The following procedure was carried out at each of pH 4, 7 and 9:
Aliquots (1 mL) of a stock solution of test material in purified water (15 g/L) were added to separate Wheaton vials containing buffer solution (9 mL), which had been purged with nitrogen and pre-equilibrated at test temperature (50 ± 0.5 °C). It was necessary to add increments of hydrochloric acid solution to the samples to maintain nominal test pH. An aliquot (20 μL) of 10M acid was added to each test solution, while an additional aliquot (15 μL) of 1M acid was added to the pH 4 and pH 9 samples only.
The samples, of nominal concentration 1.5 g/L, were placed in a 50 °C waterbath in the dark until sampling was required (immediately, and then after 2.4 and 120 hours).
At each sampling time, two samples were removed from the bath and an aliquot (1 mL) of each was diluted to volume (20 mL) with acetonitrile for analysis by gas chromatography (GC). As it became apparent that there was suppression of the response of pH 7 samples due to a matrix effect, these samples were further diluted (1 mL to 2 mL with acetonitrile) to minimize this.
Sample pH and incubation temperature were monitored over the period of the test. - Number of replicates:
- Not specified
- Positive controls:
- not specified
- Negative controls:
- not specified
- Preliminary study:
- The preliminary study showed that at each of pH 4, 7 and 9 and 50 ± 0.5 ºC, less than 10 % hydrolysis had occurred after 120 hours (5 days), equivalent to a half-life of greater than 1 year under environmental conditions (25 °C). No further testing was considered necessary.
The results show that there were no significant changes in pH and temperature with time. - Transformation products:
- not measured
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 365 d
- Type:
- not specified
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 365 d
- Type:
- not specified
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 365 d
- Type:
- not specified
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- Linearity
Under the conditions described, the calibration of the test material was found to be linear over the range 0 to 100 mg/L with a regression coefficient of 0.9997.
It was considered that the analytical method was sufficiently sensitive to quantify test item concentrations down to 10 % or less of the initial concentration. - Validity criteria fulfilled:
- yes
- Conclusions:
- The test material was determined to be hydrolytically stable under acidic, neutral and basic conditions.
- Executive summary:
A study was performed to determine the rate of hydrolysis of the test material as a function of pH. The test was conducted under GLP conditions and in accordance with the preliminary test as described in Commission Regulation (EC) No. 440/2008 (Method C.7) and the OECD Guidelines for Testing of Chemicals (Method 111).
The preliminary study showed that at each of pH 4, 7 and 9 and 50 ± 0.5 ºC, less than 10 % hydrolysis had occurred after 5 days, equivalent to a half-life of greater than 1 year under environmental conditions (25 °C). No further testing was considered necessary.
Under the conditions of the study, the test material was determined to be hydrolytically stable under acidic, neutral and basic conditions.
Reference
Description of key information
The test material was determined to be hydrolytically stable under acidic, neutral and basic conditions, OECD 111, EU Method C.7, C Pointer (2017)
Key value for chemical safety assessment
Additional information
A study was performed to determine the rate of hydrolysis of the test material as a function of pH. The test was conducted under GLP conditions and in accordance with the preliminary test as described in Commission Regulation (EC) No. 440/2008 (Method C.7) and the OECD Guidelines for Testing of Chemicals (Method 111).
The preliminary study showed that at each of pH 4, 7 and 9 and 50 ± 0.5 ºC, less than 10 % hydrolysis had occurred after 5 days, equivalent to a half-life of greater than 1 year under environmental conditions (25 °C). No further testing was considered necessary.
Under the conditions of the study, the test material was determined to be hydrolytically stable under acidic, neutral and basic conditions.
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