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EC number: 255-527-0 | CAS number: 41741-86-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance was not acutely toxic by the oral rout and after intraperitoneal application. In an inhalation risk test none of the test animals died when exposed to an atmosphere enriched with the test article for 7 hours.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Scientifically acceptable study report
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity
In an acute oral toxicity study the test substance was given to groups of 5 female and 5 male rats at concentrations of 2150 and 5000 mg/kg body weight (21.5 % and 35 % of test substance in vehicle) in an 0.5 % aqueous CMC solution. During an observation period of 14 days the clinical signs, mortality, body weight and histological signs were observed. The results showed no mortality, no clinical signs and no negative effects on the body weight (normal development). The LD50 (oral) was above 5000 mg/kg body weight.
Acute inhalation toxicity
An inhalation risk test with rats was conducted according to H .F. Smyth et al.: Am. Ind. Hyg. Ass. J. 95-107 (1962). Six male and six female rats (3 males and 3 females in two tests) were kept for 7 hours at room temperature in an atmosphere enriched with dust of the test substance. The mean concentration was 0.125 mg/L. After 7 hours no mortality was observed and no abnormality of the rat organs was detected. The results of the inhalation risk test only classify a danger, which could occur by inhalation of the test substance. The labelling of an acute toxic effect by inhalation is not possible by the test results alone.
Acute intraperitoneal toxicity
The intraperitoneal toxicity of the test substance was tested on male and female mice (strain NMRI) for a test period of 14 days. The used concentrations were 200, 700 and 2000 mg/kg bw (5 male and 5 female animals per dose rate). In the test with the highest concentration (2000 mg/kg bw) 2 male animals died within 15 minutes after trial start. Within the first hours up to day 1 living animals showed clinical signs like irregular respiration, tremor, convulsion, bad general condition, apathy or symptoms on fur and skin at all concentrations. After day 1 these symptoms disappeared. At beginning of the test a body weight stagnation was visible. At gross pathology intra-abdominal substance residues were found at the two male animals, which died first. Depending on the given dose rate the animals which were sacrificed after the test (at day 14) exhibited intra-abdominal substance residues (200 and 700 mg/kg) or intra-abdominal substance incorporations (2000 mg/kg). Due to the given results a LD50 (male/female) of >2000 mg/kg bw was determined.
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. As a result the substance is not considered to be classified for acute toxicity under Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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