Sodium bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)]chromate(1-)

Endpoint summary

Additional information

There were no studies available in which the toxicokinetic properties of the test substance were investigated. The test substance (molecular weight of 715.6 g/mol) is a brown solid powder with a log Pow of 0.81 and a water solubility of 240 mg/L at 23°C and at pH 5. The vapor pressure was not determined since the substances decomposes without melting.

In an acute toxicity study in rats no mortality and no systemic findings were observed after oral administration of test substance at a dose level of 5000 mg/kg body weight. Therefore, no conclusion can be drawn regarding systemic distribution. Generally, the smaller the molecule, the more easily it may be taken up. Molecular weights below 500 g/mol are favorable for absorption; molecular weights above 1000 g/mol do not favor absorption (ECHA GD 7c, 2008). The test article is characterized by a high molecular weight which, however, is still at a range where absorption in the gastrointestinal tract cannot be excluded. The water solubility of the test article is low, thus not favoring the substance to be readily dissolved in gastrointestinal fluids. Therefore, the potential for absorption through the gastrointestinal tract is considered to be low but cannot be ruled out. In a subacute repeated dose toxicity study (OECD 422), no toxicological relevant effects were reported up to the highest dose tested (1000 mg/kg body weight). No indications of systemic availability could be obtained in this study. The bioaccumulation potential is therefore regarded as low. Based on the sensitization studies which showed positive findings in guinea pigs, dermal penetration does occur. No data from acute or repeated dose toxicity studies by the inhalation route are available which could provide information about the systemic distribution of the test substance after inhalation. No data on the vapor pressure are available. The excretion pathway is largely dependent on molecular size, polarity and water solubility. The parent compound is expected to be excreted mainly via feces. Potential metabolites are either excreted via feces or urine, depending on their molecular size and water solubility after phase II metabolism.