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EC number: 255-449-7 | CAS number: 41583-09-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No data with the target substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied. According to Pagga, 1979 (BASF SE) a 48h-LC50 > 500 mg/L was determined on Leuciscus idus. The substance is acutely not harmful to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 500 mg/L
Additional information
No data with the target substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied. As the substance is a salt of phosphate, effects can be read-across from the cation, which is likely to have the more important effects. In biological systems, phosphate is an abundant in cells and body fluids. In ecological terms, because of its important role in biological systems, phosphate is a highly sought-after resource. Thus, read-across from the read across source substance melamine CAS 108 -78 -1 (melamine) is justified. All effect values are minimum values as the molar ratio anion:cation equals 1.74. Please refer section 13 for read across justification.
Five studies, with different reliabilities and with 4 different species of fish are available (Goodrich, 1984 (American Cyanamid Co.), Vaessen, 1982 (DSM); Pagga, 1979 (BASF SE); Nite 2010, Jansen 1978). The report of each of the 5 studies point to the same result: the acute toxicity of melamine to fish is low. The LC50s are in the range of > 500 to > 4600 mg/L.
The results of the studies are summarized in the table below. The studies revealed LC50 values clearly above the regulatorily relevant threshold of 100 mg/L. Thus it can be stated that the compound is not acutely harmful to fish.
Table 1: Summary of short-term effects on fish for the test substances
Study |
Substance |
Fish Species |
LC50(mg/L) |
American Cyanamid Co., 1984 Goodrich 1984 |
CAS 108-78-1 |
Oncorhynchus mykiss |
LC50 > 3000 mg/L |
DSM,1982 Vaessen 1982 |
CAS 108-78-1 |
Poecilia reticulata |
LC50 > 4590 mg/L |
BASF SE, 1979 Pagga 1979 |
CAS 108-78-1 |
Leuciscus idus |
LC50 > 500 mg/L |
Nite 2010 |
CAS 108-78-1 |
Oryzias latipes |
LC50 > 1000 mg/L |
ECETOC, 1983 Jansen 1978 |
CAS 108-78-1 |
Poecilia reticulata |
LC50 > 4400 mg/L |
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