[nitrilotris(methylene)]trisphosphonic acid, ammonium salt

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

other: Secondary source

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Principles of method if other than guideline:

Experimental measurement (data is taken from a reliable handbook, information about the methodology is not available)

GLP compliance:

not specified

Remarks on result:

completely miscible

No numerical result is given.

Conclusions:

The test substance is reported as miscible in water in a company MSDS. The original reference was not available for review and no further information is available. The reliability of this result is not assignable.

Reference 2

Endpoint:

water solubility

Type of information:

other: secondary source

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Principles of method if other than guideline:

Experimental measurement (data is taken from a reliable handbook, information about the methodology is not available)

GLP compliance:

no

Remarks on result:

completely miscible

Details on results:

Stable: yes

The test substance is reported as miscible in water and no other numerical data has been represented.

Conclusions:

The test substance is reported as miscible in water in a company MSDS. The original reference was not available for review and no further information is available. The reliability of this result is not assignable.

Reference 3

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Principles of method if other than guideline:

No data

GLP compliance:

not specified

Type of method:

other: No data

Remarks on result:

completely miscible

Phosphonate salts are highly water soluble and some are formulated as aqueous. Solutions containing up to 70% active material. Free acids are less soluble than the salts; however, aqueous solutions in excess of l % active material can be prepared.

An infinite water solubility value was reported in the handbook which represents the water solubility is greater than >1 *10E+6 (the substance is miscible in water).

Conclusions:

ATMP-H was reported as miscible in water in a handbook which has been subject to peer-review and in which the original data sources are traceable. The result is considered to be reliable.

Reference 4

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Principles of method if other than guideline:

Not stated

GLP compliance:

not specified

Type of method:

other: No data

Water solubility:

ca. 500 g/L

Remarks on result:

other: No information on temperature and pH

Details on results:

Stable: yes

The substance is manufactured and marketed in aqueous solutions of various pH values and concentrations. It is known that up to 50% m/m solutions can be prepared, which would have very acidic pH (see section 2.12). At pH 7 the substance is multiply-ionised and solutions of over 50% m/m can be prepared.

Conclusions:

ATMP-H was reported as miscible in water in a secondary literature. The original reference was not available for review and no further information is available. The reliability of this result is not assignable.

Reference 5

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Principles of method if other than guideline:

No data

GLP compliance:

no

Type of method:

other: No data

Water solubility:

>= 600 - <= 730 g/L

Temp.:

20 °C

Remarks on result:

completely miscible

Remarks:

Equivalent to approximately 600 to 730 g/L based on concentration of 45-55% w/w and density of 1.33 g/cm3

Conclusions:

ATMP-H was reported as completely miscible in water in a company MSDS. The original reference was not available for review and no further information is available. The reliability of this result is not assignable.

Reference 6

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Principles of method if other than guideline:

Not stated

GLP compliance:

no

Type of method:

other: No data

Water solubility:

>= 600 - <= 730 g/L

Temp.:

20 °C

Remarks on result:

completely miscible

Remarks:

Equivalent to approximately 600 to 730 g/L based on concentration of 45-55% w/w and density of 1.33 g/cm3

Conclusions:

ATMP-H was reported as miscible in water in a company MSDS. The original reference was not available for review and no further information is available. The reliability of this result is not assignable.

Reference 7

Endpoint:

water solubility

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Principles of method if other than guideline:

EPIWIN suite prediction method

GLP compliance:

no

Water solubility:

1 000 000 mg/L

Temp.:

25 °C

Remarks on result:

other: Calculation method

The water solubility value of 1000000 mg/L at 25°C was reported for ATMP-H in EPIWIN suite Ver. 4.0 cited with Gledhill WE, Feijtelm TCJ (1992). No pH condition is reported.

Conclusions:

A water solubility value of 1000000 mg/L at 25°C was reported for ATMP-H in EPIWIN suite Ver. 4.0 cited with Gledhill WE, Feijtelm TCJ (1992). No pH condition is reported. The result was obtained by weight of reliable evidence. The result was obtained by weight of reliable evidence.

Description of key information

Water solubility (ATMP-xNH4): The substance is very soluble in water and has an average water solubility value of >400 g/L at ambient conditions based on available information

Water solubility [ammonia]: 510000-531000 mg/L at 20°C

Key value for chemical safety assessment

Water solubility:

400 g/L

at the temperature of:

20 °C

Additional information

The substance ATMP-xNH4 (and its analogues) are known to be highly hydrophilic and extremely water-soluble. Although supplier's literature is much less detailed than laboratory study reports, given the range of values expected for these types of substance, the uncertainty is not significant in respect of environmental exposure or human health exposure modelling. Typical concentrations of aqueous solutions in commercial supply provides weight of evidence of high loadings. For ATMP-xNH4, the water solubility can be estimated to be equivalent to approximately >400 g/L based on concentrations of 38% for ATMP-xNH4 (pH 4) and 35% for ATMP-xNH4 (pH 7) (concentration range 25-50%) and average density of 1.2 g/cm³ at 20°C.

A water solubility of 1000000 mg/L at 25°C was reported for ATMP-H using appropriate predictive method (US Environmental Protection Agency 2008) and is cited with Gledhill WE, Feijtel, TCJ (1992). In available secondary sources to which reliability could not be assigned, water solubility in the range 500 - 730 g/L were reported for ATMP-H.

 

Phosphonate salts are highly water soluble and are supplied as aqueous solutions. The aqueous solutions of phosphonate salts are miscible in water.

Ammonia, has a reported water solubility of 510000-531000 mg/L at 20°C (OECD 2007). The reported values indicate that ammonia is highly soluble/miscible with water.

Reference:

OECD SIDS (2007). SIDS Initial Assessment Report for SIAM 24, Paris, France, 17-20 April 2007, Ammonia Category.