[nitrilotris(methylene)]trisphosphonic acid, potassium salt

Endpoint summary

Description of key information

The acute oral and dermal key studies were read across from the sodium salt (CAS 20592-85-2). T he key studies report an oral and dermal LD50 value of >10 ml/kg in rat (equivalent to >5740 mg active salt / kg bw) (Safepharm Labs, 1982; rel  1). The data for inhalation toxicity is waived as reliable data via the oral and dermal routes are available.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

5 740 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion

Dose descriptor:

LD50

Value:

5 740 mg/kg bw

Additional information

The category hypothesis is that all the members are various ionised forms of the acid 6419-19-8. The main assumption is that sodium is not significant in respect of all the properties under consideration. In dilute aqueous conditions of defined pH a salt will behave no differently to the parent acid, at identical concentration of the particular speciated form present and will be fully dissociated. Hence some properties (measured or expressed in aqueous media) for a salt can be directly read-across (with suitable mass correction) to the parent acid and vice versa.

Justification for classification or non-classification

Based on the available information, there is no requirement for the classification or labelling of the[nitrilotris(methylene)]trisphosphonic acid, potassium salt in accordance with current EU guideline.