Registration Dossier
Registration Dossier
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EC number: 248-471-3 | CAS number: 27458-94-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In an Ames test, Salmonella typhimuriumstrains TA 98, TA 100, TA 1535, TA 1537 and TA 1538 were treated with Isononanol by the test plate incorporation method as well as the pre-incubation method. Dose levels covered the range of 10 to 5000 µg/plate, in triplicate both with and without the addition of metabolising system (S9 mix). A reproducible mutagenic activity of the test substance to any of the tester strains was not observed with and without metabolic activation. Isononanol is therefore considered not to be a bacterial mutagen. The study was well documented and conducted to EU test guidelines, although not to GLP.
In a second Ames test with Isononanol, employing only four strains of Salmonella typhimurium, no mutagenic activity was detected
Short description of key information:
No indications of genotoxicity or mutagenicity.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
No classification for genetic toxicity is indicated according to the general classification and labeling requirements for dangerous substances and preparations (Directive 67-548-EEC) or the classification, labeling and packaging (CLP) regulation (EC) No 1272/2008.
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