Registration Dossier
Registration Dossier
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EC number: 248-003-8 | CAS number: 26787-78-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Weight of evidence: Test method equivalent to OECD 202. No GLP. The 48h-EC50 for the immobilisation of D. magna was > 1000 mg/L (nominal).
Weight of evidence: Test method equivalent to OECD 202 No GLP. The 48h-EC50 for the immobilisation of M. macropoda was > 1000 mg/L (nominal).
Weight of evidence: Test method similar to OECD 202. No GLP. The 96h-EC50 was 6950 mg/L based on mobility (nominal concentration:
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1 000 mg/L
Additional information
A short-term toxicity study to invertebrates was performed by Park et al. (2008) according to EPA 821/R-02/012. Five Daphnia magna (<24h old) per dose and replicate (4 replicates) were exposed up to 1000 mg/L amoxicillin for 48 hours. The acute toxicity test using M. macrocopa was conducted following the same method. For both species, the 48h-EC50 was determined to be > 1000 mg/L based on mobility. No data on analytical monitoring was reported.
In another study, Iannacone et al. (2009) exposed Daphnia magna (<24h old) to 0, 125, 250, 500, 1000 and 2000 mg/L of amoxicillin plus control for 96 hours. The 96h-EC50 was determined to be 6950 mg/L based on mobility. The stability of the substance was not
evaluated.
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