Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-003-8 | CAS number: 26787-78-0
Biodegradation in soil
Administrative data
Link to relevant study record(s)
Description of key information
Data waiving (other justification): According to REACH regulation, Anex IX, colum 2, the study need not be conducted if direct and indirect exposure of soil is unlikely.
Nevertheless, a study on amoxicillin’s persistence in soil was conducted by Braschi et al. (2013). The persistence of amoxicillin at wilting point and the field capacity were analysed in two soils from northern Italy (Bologna area). No concentration decrease was detected in 3 weeks' observation. According to the authors, its unreactivity in soils could be related to its physical state (powder). Persistence at field capacity (T ½) was determined to be in the range of 0.43-0.57 days and with consistent contribution of the abiotic component to overall degradation (T ½ = 1.74-0.59 days autoclaved soils S1 and S2). No data was provided on transformation/degradation products.
Key value for chemical safety assessment
Additional information
Data waiving (other justification): According to REACH regulation, Anex IX, colum 2, the study need not be conducted if direct and indirect exposure of soil is unlikely.
Nevertheless, a study on amoxicillin’s persistence in soil was conducted by Braschi et al. (2013). The persistence of amoxicillin at wilting point and the field capacity were analysed in two soils from northern Italy (Bologna area). No concentration decrease was detected in 3 weeks' observation. According to the authors, its unreactivity in soils could be related to its physical state (powder). Persistence at field capacity (T ½) was determined to be in the range of 0.43-0.57 days and with consistent contribution of the abiotic component to overall degradation (T ½ = 1.74-0.59 days autoclaved soils S1 and S2). No data was provided on transformation/degradation products.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
