Registration Dossier
Registration Dossier
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EC number: 242-419-3 | CAS number: 18547-93-8
Endpoint summary
Administrative data
Description of key information
In the key acute oral toxicity study with 1,1,3,3-tetramethyldisiloxane-1,3-diyl)dipropane-1,3-diyl dimethacrylate, the reported LD50 value was greater than 2000 mg/kg bw (Eurofins, 2017).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the key acute oral toxicity study with 1,1,3,3-tetramethyldisiloxane-1,3-diyl)dipropane-1,3-diyl dimethacrylate, the reported LD50 value was greater than 2000 mg/kg bw (Eurofins, 2017).
Two groups of three female rats were treated with the test item by oral gavage administration at a dosage of 2000 mg/kg body weight. The test item was administered according to the body weight of the animals. The animals were observed on delivery, on inclusion in the study and before administration for mortality/morbidity and other clinical signs. All animals were examined for clinical signs several times on the day of dosing and once daily until the end of the observation period. Their body weights were recorded on day 1 (prior to the administration) and on days 8 and 15. All animals were necropsied and examined macroscopically. All animals survived until the end of the study without showing any test-item related signs of toxicity. Throughout the 14-day observation period, the body weight gain of the test animals was within the normal range of variation for this strain. At necropsy, no treatment-related macroscopic findings were observed.
Justification for classification or non-classification
Based on the available data for 1,1,3,3-tetramethyldisiloxane-1,3-diyl)dipropane-1,3-diyl dimethacrylate, no classification for acute toxicity is required according to Regulation (EC) No 1272/2008.
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