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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Endpoint summary

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Administrative data

Key value for chemical safety assessment

Effects on fertility

Additional information

The only repeated dose toxicity data available are from a seven-day range-finding study. As a result of the corrosive findings in this study, the following was concluded regarding the full OECD TG 422 study:

"The results and concerns regarding animal welfare were discussed with the EPA and resulted in EPA's acceptance of the Sponsor's request for a reduced testing rationale for ethyltriacetoxysilane. The reduced testing rationale included not conducting the combined repeated dose toxicity with the reproductive/developmental toxicity screening test for ethyltriacetoxysilane in Sprague-Dawley rats. In addition, ethyltriacetoxysilane was reviewed at SIAM 21 where it was determined that this chemical possesses properties indicating a hazard for human health (severe irritation and corrosivity caused by acetic acid)."

In response to the EPA's acceptance of reduced testing rationale the full OECD TG 422 study was cancelled.


Short description of key information:
In a seven-day range-finding study conducted to determine appropriate doses for administration in an OECD TG 422 study, a NOAEL could not be determined for triacetoxyethylsilane due to the corrosive effects of this substance on the oesophagus and stomach (DCC, 2004). The study was not conducted to a guideline or to GLP as it was a range-finder only.

On the basis of this result and the results of the skin corrosion studies, it is concluded that it is not feasible to conduct the OECD TG 422 study, which is in agreement with the decision of the US EPA.

Effects on developmental toxicity

Description of key information
In a seven-day range-finding study conducted to determine appropriate doses for administration in an OECD TG 422 study, a NOAEL could not be determined for triacetoxyethylsilane due to the corrosive effects of this substance on the oesophagus and stomach (DCC, 2004). The study was not conducted to a guideline or to GLP as it was a range-finder only.
On the basis of this result and results of the skin corrosion studies, it is concluded that it is not feasible to conduct the OECD TG 422 study, which is in agreement with the decision of the US EPA.
Additional information

The only repeated dose toxicity data available are from a seven-day range-finding study. As a result of the corrosive findings in this study, the following was concluded regarding the full OECD TG 422 study:

"The results and concerns regarding animal welfare were discussed with the EPA and resulted in EPA's acceptance of the Sponsor's request for a reduced testing rationale for ethyltriacetoxysilane. The reduced testing rationale included not conducting the combined repeated dose toxicity with the reproductive/developmental toxicity screening test for ethyltriacetoxysilane in Sprague-Dawley rats. In addition, ethyltriacetoxysilane was reviewed at SIAM 21 where it was determined that this chemical possesses properties indicating a hazard for human health (severe irritation and corrosivity caused by acetic acid)."

In response to the EPA's acceptance of reduced testing rationale the full OECD TG 422 study was cancelled.

Justification for classification or non-classification

Triacetoxyethylsilane is not classified for reproductive or developmental effects by any route according to Regulation 1272/2008/EC.

Additional information