Registration Dossier
Registration Dossier
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EC number: 241-482-4 | CAS number: 17465-86-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity threshold value (EC10) of the read-across substance .beta.-cyclodextrin is > 10000 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 10 000 mg/L
Additional information
The read-across approach based on grouping of substances (category approach) is used due to the following reason: .alpha.-, .beta.- and .gamma.-cyclodextrin consist of α-D-glucopyranoside units in a ring structure of 6, 7, and 8 units, respectively. Water solubility of these compounds is between 18 and 232 g/L at 25°C. The typical biodegradation route is a ring opening in the first step and then cleavage to oligo- or mono-saccharide units and further metabolisation to CO2. All degradation intermediates are practical nontoxic. Bioaccumulation is not expected due to the log Pow values ranging from -12.02 up to -7.77.
The read across substance .beta.-cyclodextrin was investigated for its ability to inhibit the cell multiplication of the bacteria species Pseudomonas putida according to DIN 38412 Part L 8 (March 1991) and NEN-EN-ISO 10712 (1996).Based on the results of these test the toxicity threshold value (EC10) of .beta.-cyclodextrin is > 10,000 mg/L.
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