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EC number: 241-477-7 | CAS number: 17463-34-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral:
-rat, LD50 (Dodecylamine): >2000 mg/kg
-rat, LD50 (coco alkylamines): > 2000 mg/kg
-rat, LD50 (octanoic acid): 1410 mg/kg
-rat, LD50 (coco alkylamines): 1300 mg/kg
-rat, LD50 (Octylamine): 200- 500 mg/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Value:
- mg/kg bw
Additional information
There is no experimental data on acute toxicity for caprylamine caprylate. The acute toxicity of caprylamine caprylate is derived from the available data of octanoic acid, dodecylamine and coco (source chemicals).
No acute toxicity potential was derived in one study with dodecylamine and one study with coco alkylamines (LD50 > 2000 mg/kg). However, there is data indicating the LD50 of octanoic acid is 1410 mg/kg in rat. And in another acute toxicity study for coco alkylamines, the LD50 was determined to be 1300 mg/kg in rat.
The LD50 of octylamine is tested to be in the range of 200 - 500 mg/kg. However, in the acute toxicity study of octylamine,
10 animals each were treated at doses of 500 and 200 mg/kg bw. At 500 mg/kg bw 9/10 animals died within 24 hours. But at 200 mg/kg bw the animals did not show any systemic toxicity already one day after the treatment and the body weight development in the observation period of 14 days seems to be not affected. It can be assumed that the mortality was due to the local effect and/or immediate chemical shock, but less likely due to systemic organ toxicity. The cut-off value for Cat3/Cat4 for acute toxicity is 300 mg/kg bw. Given that the dose level difference for 200 and 300 mg/kg bw corresponds to 50% increase from the non-toxic dose level, a mortality higher than 50% at 300 mg/kg bw cannot be assumed. Furthermore, the target chemical caprylamine caprylate is an ionic compound that results from the neutralization reaction of the compounds of octanoic acid and octylamine. If considering the target substance as a mixture of octanoic acid and octylamine, the acute toxicity estimate (ATE) can be calculated by the equation 100/ATEmix = Σ Ci/ATEi according to "Guidance on the application of the CLP criteria" (ECHA 2013). Where Ci is the concentration of ingredient, ATEi is the ATE of ingredient i. Based on the molecular weight and LD50 values of octanoic acid and octylamine, the ATE of caprylamine caprylate is calculated to be 360 mg/kg. Considering all the information available, caprylamine caprylate is classified as Cat.4 for acute oral toxicity,according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
The analogue approach using octanoic acid, octylamine, dodecylamine and coco alkylamines source chemicals is justified:
The target chemical caprylamine caprylate is an ionic compound that results from the neutralization reaction of the compounds of octanoic acid and octylamine. In aqueous solution or in a biological fluid, it could be dissociate as octanoic acid and octylamine. Therefore, the toxicity toxicological profile of the target chemical should be comparable to that of octylamine and octanoic acid. Based on the basic concept of “chain length category”, the use of toxicity data of other fatty amines for read-across purpose to octylamine and the target chemical is justified. The dissociated product of the target chemical – octylamine and the source chemicals of dodecylamine and coco alkylamines belong to the homologues series of fatty amines and form a “chain length category”, where there is an incremental increase in the number of CH2 units. Therefore, it can be reasonably assumed that octylamine and other fatty amines (dodecylamine and coco alkylamines) share the same toxic mode of action.
All the chemicals are assessed using the rule based expert system DEREK Nexus based on their chemical structures. The assessment results are identical for the target chemical octylamine, dodecylamine and coco alkylamines: all the chemicals are predicted as negative for mutagenicity in bacteria. No toxicity potential or structure alert is identified.
Justification for classification or non-classification
Based on the available data, the substance is classified as Cat.4 for acute oral toxicity, according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
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