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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February 2022 - July 2022
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Version / remarks:
OECD, May 1981
Deviations:
not specified
GLP compliance:
yes (incl. QA statement)
Dissociating properties:
yes
No.:
#1
pKa:
0.909
Temp.:
20 °C
Remarks on result:
other: pKa1 calculated from pKa2
No.:
#2
pKa:
2.91
Temp.:
20 °C
Remarks on result:
other: pKa2 experimentally determined
Conclusions:
At 20 ± 1 °C and with a dihydrogen hexafluorotitanate concentration of 7.93 mM the test substance has two different ionizable functional groups, with an apparent pKa2 of 2.91 (experimentally determined) and pKa1 of 0.909 (calculated from pKa2).
Executive summary:

The dissociation constant of the test substance was determined in a GLP study according to OECD 112. A dilute solution (7.93 mM) of dihydrogen hexafluorotitanate was titrated with a standardized base solution to determine if there were any equivalence or half points of the test solution which would indicate conjugate species.


RESULTS: Testing was conducted at 20 ± 1 °C with dihydrogen hexafluorotitanate at a concentration of 7.93 mM. The data demonstrates that dihydrogen hexafluorotitanate has two different ionizable functional groups, with an apparent pKa2 of 2.91 (experimentally determined) and pKa1 of 0.909 (calculated from pKa2). Likewise, for the reference material, the experimental and calculated pKa values of oxalic acid were pKa2 of 3.46 and pKa1 of 1.92, respectively.

Description of key information

Substance has two different ionizable functional groups, with an apparent pKa2 of 2.91 (experimentally determined) and pKa1 of 0.909 (calculated from pKa2).

Key value for chemical safety assessment

Additional information