Registration Dossier
Registration Dossier
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EC number: 241-034-8 | CAS number: 16961-83-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- see read acros justification
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 43 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: fluoride ion (F-)
- Basis for effect:
- biomass
- Remarks on result:
- other: Scenedesmus sp.
- Remarks:
- freshwater
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 122 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: fluoride ion (F-)
- Basis for effect:
- biomass
- Remarks on result:
- other: Selenastrum capricornutum
- Remarks:
- freshwater
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 81 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: fluoride ion (F-)
- Basis for effect:
- biomass
- Remarks on result:
- other: Skeletonema costatum
- Remarks:
- marine
- Duration:
- 7 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- other: fluoride ion (F-)
- Basis for effect:
- biomass
- Remarks on result:
- other: Ankistridesmus braunii, Cyclotella menghiniana, Oscillatoria limnetica, Scenedesmus quadricauda, Stephanodiscus minutus, Synechococcus leopoldiensis
- Remarks:
- freshwater
- Duration:
- 8 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 249 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: fluoride ion (F-)
- Basis for effect:
- biomass
- Remarks on result:
- other: Scenedesmus quadricauda
- Remarks:
- freshwater
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 50 - <= 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: fluoride ion (F-)
- Basis for effect:
- biomass
- Remarks on result:
- other: Amphidnium carteri, Chaetoceros gracilis, Dunaliella tertiolecta, Pvlova lutheri
- Remarks:
- marine
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 50 - <= 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: fluoride ion (F-)
- Basis for effect:
- biomass
- Remarks on result:
- other: Amphidnium carteri, Chaetoceros gracilis, Dunaliella tertiolecta, Pvlova lutheri
- Remarks:
- marine
- Details on results:
- The EC50 values for freshwater algae ranged from 43 to 122 mg F-/L. For marine algae the EC50 was 81 mg F-/L for Skeletonema costatum.
Applying the conversion factor from F- to hexafluorosilicic acid, the concentration range corresponds to 54.2 - 153.7 and 102 mg hexafluorosilicic acid/L for freshwater and marine algae, respectively. - Results with reference substance (positive control):
- Not relevant
- Reported statistics and error estimates:
- Not relevant
- Executive summary:
The EU RAR reviews and summarises the available data on the toxicity of sodium fluoride to freshwater and marine algae species. The EC50 values (expressed in terms of fluoride ion, F-) for freshwater algae are reported to range from 43 to 122 mg/L. For marine algae the EC50 was 81 mg/L in a single study with Skeletonema costatum. NOEC values of 50 -249 mg F-/L and 50 -200 mg F-/L are reported for freshwater and marine algae, respectively.
Applying the conversion factor from F- to hexafluorosilicic acid, the concentration range for EC50 values corresponds to 54.2 - 153.7 and 102 mg hexafluorosilicic acid/L for freshwater and marine algae, respectively. The NOEC values corresponds to 63 - 314 and 63 - 252 mg hexafluorosilicic acid/L for freshwater and marine algae, respectively.
For conservative reasons the EC50 values of 54.2 and 102 mg/L will be used for the risk assessment for freshwater and marine algae, respectively.
For conservative reasons the NOEC values of 63 mg/L will be used for the risk assessment for freshwater and marine algae.
Reference
Expressed in terms of fluoride ion (F-), EC50 values for freshwater algae range from 43 to 122 mg F-/L, with NOEC values of 50 -249 mg F-/L. For marine algae the EC50 was 81 mg F-/L for Skeletonema costatum; NOEC values of 50 -200 mg F-/L are reported however the EU RAR states that these values should be used with caution due to the relatively long exposure time of 14 -21 days.
Description of key information
For conservative reasons the EC50 values of 54.2 and 102 mg/L will be used for the risk assessment for freshwater and marine algae, respectively.
For conservative reasons the NOEC values of 63 mg/L will be used for the risk assessment for freshwater and marine algae.Key value for chemical safety assessment
- EC50 for freshwater algae:
- 54.2 mg/L
- EC50 for marine water algae:
- 102 mg/L
- EC10 or NOEC for freshwater algae:
- 63 mg/L
- EC10 or NOEC for marine water algae:
- 63 mg/L
Additional information
The EU RAR reviews and summarises the available data on the toxicity of sodium fluoride to freshwater and marine algae species. The EC50 values (expressed in terms of fluoride ion, F-) for freshwater algae are reported to range from 43 to 122 mg/L. For marine algae the EC50 was 81 mg/L in a single study with Skeletonema costatum. NOEC values of 50 -249 mg F-/L and 50 -200 mg F-/L are reported for freshwater and marine algae, respectively.
Applying the conversion factor from F- to hexafluorosilicic acid, the concentration range for EC50 values corresponds to 54.2 - 153.7 and 102 mg hexafluorosilicic acid/L for freshwater and marine algae, respectively. The NOEC values corresponds to 63 - 314 and 63 - 252 mg hexafluorosilicic acid/L for freshwater and marine algae, respectively.
For conservative reasons the EC50 values of 54.2 and 102 mg/L will be used for the risk assessment for freshwater and marine algae, respectively.
For conservative reasons the NOEC values of 63 mg/L will be used for the risk assessment for freshwater and marine algae.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
