Registration Dossier
Registration Dossier
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EC number: 238-639-4 | CAS number: 14593-46-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No studies for acute toxicity with sodium 2-methylbutan-2-olate are available. According to the REACh Regulation (EC) No 1907/2006, Article 18.2 no further studies need to be conducted. The available data regarding skin irritation demonstrate that Sodium 2-methylbutan-2-olate has a corrosive potential to skin. According to the REACh Regulation (EC) No 1907/2006, Annex VII and Annex VII, column 2 point 8.5 a study of acute toxicity does not need to be performed if the substance is classified as corrosive to skin. The test substance hydrolyses rapidly in contact with water into 2-methylbutan-2-ol and sodium hydroxide. Therefore, the hydrolysis products are considered to be relevant for acute toxicity.
Justification for classification or non-classification
The test substance hydrolyses rapidly in contact with water. Therefore, the hydrolysis products are considered to be relevant for classification according to CLP Regulation (EC) No 1272/2008. For both hydrolysis products disseminated dossiers are available on the homepage of ECHA.
The hydrolysis product sodium hydroxide (CAS No. 1310-73-2) showed no acute toxicity and is not classified for acute toxicity. The second product 2-methylbutan-2-ol (CAS No. 75-85-4) is not classified as orally toxic. However, it is classified as acute toxic category 4 by inhalation route according to Annex VI of the CLP Regulation (EC) No 1272/2008 and is classified as acute toxic by the dermal exposure route according to the disseminated dossier. Based on this data, the test substance should also be classified as acute toxic, category 4 by dermal and inhalative route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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