Registration Dossier
Registration Dossier
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EC number: 236-826-5 | CAS number: 13499-05-3
Endpoint summary
Administrative data
Description of key information
On the basis of column 2 of REACH annex VIII, and in accordance with REACH Annex XI, section 2, testing is technically not feasible since the registered substance is not stable and degrades instantaneously. In these conditions, the repeated toxicity is not relevant and the substance needs to be estimated considering the toxicity of its degradation products, that is to say long term toxicity of HCl and HfOCl2 then HfO2.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: oral
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Critical effects observed:
- not specified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - systemic effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Critical effects observed:
- not specified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Critical effects observed:
- not specified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: dermal
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Critical effects observed:
- not specified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: dermal
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Critical effects observed:
- not specified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Hafnium tetrachloride undergoes rapid degradation in presence of water or humidity, it is therefore not stable in contact of moist skin or mucous membranes and degrades in HCl and in an equilibrium of HfOCl2 / HfO2.
Testing HfCl4 for long term toxicity is for this reason not relevant at all, but degradation products have to be considered.
Hydrogen chloride was already registered in the frame of REACh and classified as acutely toxic by inhalation as long term studies showed only local effects.
HfOCl2 and HfO2, by read across with ZrOCl2 and ZrO2 (see justification for read across in toxicological summary section 7) are considered as not hazardous substances and are not classified at all for human health effects.
For repeated toxicity, the assessment was based on two reliable studies:
- a 17 weeks oral study with hydrated zirconium carbonate, on rat (NOAEL > 3150 mg/kg bw/d)
- and a 30 day inhalation test in dog, rabbit and rat + a 60 day test in cat, dog, guinea pig, rabbit and rat. No effects were reported in any of the species studied after inhalation of ZrO2 dust (NOAEC > 75 mg ZrO2/m3 air in the 30 day study and NOAEC > 11 mg ZrO2/m3 air in the 60 day study).
Justification for classification or non-classification
Hafnium tetrachloride undergoes rapid degradation in presence of water or humidity, it is therefore not stable in contact of moist skin or mucous membranes and degrades in HCl and in an equilibrium of HfOCl2 / HfO2.
Testing HfCl4 for long term toxicity is for this reason not relevant at all, in the same way, no classification is needed.
Nevertheless, degradation products have to be considered, and they are already classified :
- Hydrogen chloride was registered in the frame of REACh in 2010. HCl is classified as acutely toxic by inhalation as long term studies showed only local effects.
- HfOCl2 and HfO2, by read across with ZrOCl2 and ZrO2 (see justification for read across in toxicological summary section 7) are considered as not hazardous substances and are not classified at all for human health effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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