Registration Dossier
Registration Dossier
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EC number: 235-835-1 | CAS number: 13001-39-3
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- May 11, 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- flask method
- Water solubility:
- < 20 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 4 h
- Temp.:
- 20 °C
- pH:
- ca. 6.4
- Conclusions:
- Approximate solubility: << 20 mg/l (20 °C; pH 6.40 saturated solution).
- Executive summary:
Method
OECD guideline 105 - shake flask method.
Result
Approximate solubility << 20 mg/l at 20 °C and pH 6.40.
- Endpoint:
- water solubility
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Weight of evidence approach based on available experimental data as well as predicted data.
- Principles of method if other than guideline:
- Estimate by WSKOWWIN v1.42 as implemented in EPI Suite v4.11.
- Water solubility:
- < 0.024 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: estimated using no-melting point equation
- Conclusions:
- Estimated water solubility at 25 °C is 0.024 mg/l.
- Executive summary:
Method
Estimate of partition coefficient carried out by WSKOWWIN v1.42 as implemented in EPI Suite v4.11.
Results
Estimated water solubility at 25 °C is 0.024 mg/l.
Referenceopen allclose all
Preliminary solubility results
Reference samples and extract were first measured in the range 190/800 nm, so as to choose the right wavelength for quantitative measurements.
The extract showed absorption only in UV region. This was due to the presence of a water-soluble component, which differed from the main product.
Test results
Considering that the product was not completely soluble in reference solution, and that the absorbance of test solutions were below the sensibility limit of the instrument in visible region, just an approximate solubility was determined.
Approximate solubility: << 20 mg/l
pH mother solution: 4.54
pH satured solution: 6.40
Description of key information
Not soluble.
Key value for chemical safety assessment
- Water solubility:
- 0.024 mg/L
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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